Thapsigargin
| Name | Thapsigargin |
|---|---|
| Supplier | Abcam |
| Catalog | ab120286 |
| Cas Number | 67526-95-8 |
| Pubchem | 446378 |
| Chemical Name | (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate |
| Formula | C34H50O12 |
| Molecular Weight | 650.76 |
| Purity | > 98% |
| Description | Ca2+-ATPase inhibitor |
| Supplier Page | Shop |
Product images
ab58668 staining ATF3 in serum starved A549 cells treated with thapsigargin (ab120286), by ICC/IF. Increase of ATF3 correlates with increased concentration of thapsigargin, as described in literature.The cells were incubated at 37°C for 1h in media containing different concentrations of ab120286 (thapsigargin) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab58668 (10 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
Product References
Molecularly distinct routes of mitochondrial Ca2+ uptake are activated depending - Molecularly distinct routes of mitochondrial Ca2+ uptake are activated depending
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Inhibition of STIM1 phosphorylation underlies resveratrol-induced inhibition of - Inhibition of STIM1 phosphorylation underlies resveratrol-induced inhibition of
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Effect of dexamethasone on Na+/Ca2+ exchanger in dendritic cells. - Effect of dexamethasone on Na+/Ca2+ exchanger in dendritic cells.
Heise N, Shumilina E, Nurbaeva MK, Schmid E, Szteyn K, Yang W, Xuan NT, Wang K, Zemtsova IM, Duszenko M, Lang F. Am J Physiol Cell Physiol. 2011 Jun;300(6):C1306-13. doi: