7-Chlorokynurenic acid sodium salt
| Name | 7-Chlorokynurenic acid sodium salt |
|---|---|
| Supplier | Abcam |
| Catalog | ab120255 |
| Pubchem | 52974249 |
| Chemical Name | 7-Chloro-4-hydroxyquinoline-2-carboxylic acid sodium salt |
| Formula | C10H5ClNNaO3 |
| Molecular Weight | 245.60 |
| Purity | > 99% |
| Description | NMDA receptor glycine site antagonist; water soluble |
| Supplier Page | Shop |
Product images
ab12416 staining cGMP in SKNSH cells treated with 7-Chlorokynurenic acid sodium salt (ab120255), by ICC/IF. Decrease in cGMP expression correlates with increased concentration of 7-Chlorokynurenic acid sodium salt, as described in literature.The cells were incubated at 37°C for 30 minutes in media containing different concentrations of ab120255 (7-Chlorokynurenic acid sodium salt) in DMSO. Some samples where then further incubated with 1 mM glutamate (ab120049) for 15 minutes and all samples were fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab12416 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.