α-Dendrotoxin
| Name | α-Dendrotoxin |
|---|---|
| Supplier | Abcam |
| Catalog | ab141791 |
| Cas Number | 74504-53-3 |
| Chemical Name | QPRRRKLCILHRNPGRCYDKIPAFYYNQKKKQCERFDWSGCGGNSNRFKTIEECRRTCIG Disulfide bonds between Cys7-Cys57, Cys16-Cys40 and Cys32-Cys53. Gln1 - Pyrrolidone carboxylic acid. |
| Formula | C305H481N99O84S6 |
| Molecular Weight | 7065.00 |
| Purity | > 98% |
| Description | Potent and selective Kv1 channel blocker |
| Supplier Page | Shop |
Product images
a-Dendrotoxin inhibits KV1.1 and KV1.2 channel currents heterologously expressed in Xenopus oocytes. KV1.1 (left, in 2 mM K+) and KV1.2 (right, in 5 mM K+) channel currents elicited by 200 ms depolarization from a holding potential of -100 mV to +20 mV, before and during application of 100 nM a-Dendrotoxin (ab141791). 73% (n = 4) of the KV1.1 and 80% (n = 4) of the KV1.2 channels were inhibited by a-Dendrotoxin , respectively.