ENSA
| Gene Symbol | ENSA |
|---|---|
| Entrez Gene | 2029 |
| Alt Symbol | ARPP-19e |
| Species | Human |
| Gene Type | protein-coding |
| Description | endosulfine alpha |
| Other Description | alpha-endosulfine |
| Swissprots | Q6FHW0 Q5T5H2 Q6VUC9 Q6VUD1 Q6VUC8 Q6NUL2 Q6IAM4 Q6VUC7 E9PB69 Q9NRZ0 Q6VUD0 Q68D48 Q6VUC6 O43768 A8K1Z9 |
| Accessions | AAQ73827 AAQ73828 AAQ73829 AAQ73830 AAQ73831 AAQ73832 CAB65125 EAW53528 EAW53529 EAW53530 EAW53531 EAW53532 EAW53533 O43768 AF067170 AAD32454 AF157509 AAF80340 AF157510 AAF80341 AK001981 BAG50998 AK057673 AK290064 BAF82753 AL711949 AW136940 AW409955 BC000436 AAH00436 BC004461 AAH04461 BC068544 AAH68544 BC069208 AAH69208 BE799496 BM771663 BM984677 BM993811 BQ005654 BQ883543 BU075511 BU858280 CB243574 CR457130 CAG33411 CR536578 CAG38815 CR749580 CAH18372 EU832303 ACE87560 EU832387 ACE86872 T78564 X99906 CAA68180 NM_004436 NP_004427 NM_207042 NP_996925 NM_207043 NP_996926 NM_207044 NP_996927 NM_207045 NP_996928 NM_207046 NP_996929 NM_207047 NP_996930 NM_207168 NP_997051 |
| Function | Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. {ECO:0000250, ECO:0000269|PubMed:9653196}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. |
| Tissue Specificity | Widely expressed with high levels in skeletal muscle and brain and lower levels in the pancreas. {ECO:0000269|PubMed:14728987, ECO:0000269|PubMed:9653196}. |
ENSA CRISPR/Cas9 KO Plasmid (h) - sc-403380 from Santa Cruz Biotechnology
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ENSA HDR Plasmid (h) - sc-403380-HDR from Santa Cruz Biotechnology
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ENSA Double Nickase Plasmid (h) - sc-403380-NIC from Santa Cruz Biotechnology
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ENSA Double Nickase Plasmid (h2) - sc-403380-NIC-2 from Santa Cruz Biotechnology
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ENSA CRISPR Activation Plasmid (h) - sc-403380-ACT from Santa Cruz Biotechnology
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ENSA CRISPR Activation Plasmid (h2) - sc-403380-ACT-2 from Santa Cruz Biotechnology
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ENSA Lentiviral Activation Particles (h) - sc-403380-LAC from Santa Cruz Biotechnology
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ENSA Lentiviral Activation Particles (h2) - sc-403380-LAC-2 from Santa Cruz Biotechnology
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ENSA siRNA (h) - sc-78564 from Santa Cruz Biotechnology
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ENSA shRNA Plasmid (h) - sc-78564-SH from Santa Cruz Biotechnology
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ENSA shRNA (h) Lentiviral Particles - sc-78564-V from Santa Cruz Biotechnology
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alpha Endosulfine RNAi - H00002029-R07 from Novus Biologicals
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alpha Endosulfine RNAi - H00002029-R05 from Novus Biologicals
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alpha Endosulfine RNAi - H00002029-R03 from Novus Biologicals
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alpha Endosulfine RNAi - H00002029-R02 from Novus Biologicals
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alpha Endosulfine RNAi - H00002029-R01 from Novus Biologicals
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MISSION® esiRNA - EHU098471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7887 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7887 from Sigma-Aldrich
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ENSA siRNA (Human) - CRH1408 from Cohesion Biosciences
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alpha Endosulfine RNAi - H00002029-R04 from Novus Biologicals
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alpha Endosulfine RNAi - H00002029-R08 from Novus Biologicals
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alpha Endosulfine RNAi - H00002029-R06 from Novus Biologicals
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ENSA - MBS8221524 from MyBioSource
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shRNA set against Human ENSA(NM_207043.1) - SHH034373 from Creative biogene
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