| Gene Symbol | shk1 |
|---|---|
| Entrez Gene | 2539997 |
| Alt Symbol | orb2, pak1 |
| Species | S. pombe |
| Gene Type | protein-coding |
| Description | PAK-related kinase Shk1 |
| Other Description | - |
| Swissprots | P50527 |
| Accessions | CAA22347 P50527 NM_001022547 NP_596626 |
| Function | MAP4K component of the MAPK pathway required for the mating pheromone response. Phosphorylates histone H2B to form H2BS10ph (By similarity). Phosphorylates tea1. Required for skb1- dependent mitotic inhibitory function. Regulates microtubule dynamics and cell polarity. {ECO:0000250, ECO:0000269|PubMed:10574765, ECO:0000269|PubMed:11972773, ECO:0000269|PubMed:12764130, ECO:0000269|PubMed:7597098, ECO:0000269|PubMed:8846783, ECO:0000269|PubMed:8943016, ECO:0000269|PubMed:9843966}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11972773}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11972773}. Note=Localizes at cell ends, septum forming regions and at the mitotic spindle. |
| Top Pathways | MAPK signaling pathway - yeast |