| Gene Symbol |
CASP14
|
| Entrez Gene |
23581
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
caspase 14, apoptosis-related cysteine peptidase
|
| Other Description |
CASP-14|apoptosis-related cysteine protease|caspase 14, apoptosis-related cysteine protease|caspase-14
|
| Swissprots |
O95823 Q3SYC9 P31944
|
| Accessions |
EAW84459 P31944 AF097874 AAD16173 AK313992 BAG36704 BC069541 AAH69541 BC103868 AAI03869 BC103869 AAI03870 BM840054 EU262664 ABX83060 EU502748 ACA63845 HQ448424 ADQ32904 XM_011527861 XP_011526163 NM_012114 NP_036246
|
| Function |
Believed to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm. Nucleus.
|
| Tissue Specificity |
Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands (at protein level). In psoriatic skin only expressed at very low levels. {ECO:0000269|PubMed:11175259}.
|
