PRNP

Gene Symbol PRNP
Entrez Gene 5621
Alt Symbol ASCR, AltPrP, CD230, CJD, GSS, KURU, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, p27-30
Species Human
Gene Type protein-coding
Description prion protein
Other Description CD230 antigen|major prion protein|prion-related protein
Swissprots Q96E70 Q9UP19 Q8TBG0 P78446 F7VJQ1 Q15221 O60489 Q15216 Q27H91 Q5QPB4 P04156
Accessions AAB20521 AAB20522 AAB20523 AAB21334 AAB35416 AAB50648 AAB50649 AAB50777 AAB59442 AAB59443 AAC05365 AAC62750 AAC78725 AAD15012 AAD46098 AAO83635 AAO83636 AAR21603 ABD63004 ABL75508 ADD71057 ADO16981 CAA58442 DAA34790 EAX10449 EAX10450 F7VJQ1 P04156 AB300823 BAG32276 AB300824 BAG32277 AB300825 BAG32278 AB300826 BAG32279 AK090575 BAG52189 AK293312 BAG56832 AK295415 BAG58365 AK295943 BAG58727 AK312276 BAG35206 AW452130 AY008282 AAG21693 AY569456 AAS80162 BC012844 AAH12844 BC016809 BC022532 AAH22532 BG397054 BI669189 BP251427 BT019496 AAV38303 CR542039 CAG46836 CR542072 CAG46869 D00015 BAA00011 DA122620 DA297032 DB461478 DQ891318 ABM82244 DQ894502 ABM85428 M13667 AAA19664 M13899 AAA60182 X82545 CAA57895 NM_000311 NP_000302 NM_001080121 NP_001073590 NM_001080122 NP_001073591 NM_001080123 NP_001073592 NM_001271561 NP_001258490 NM_183079 NP_898902
Function May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of CU(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.
Tissue Specificity Detected in brain homogenate, primary neurons, and peripheral blood mononuclear cells (at protein level). {ECO:0000269|PubMed:21478263}.
Top Pathways Prion diseases

PRNP (D3Q5C) Rabbit mAb - 14025 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3Q5C
Western blot analysis of extracts from various tissues and cell lines using PRNP (D3Q5C) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

PrP (G-12) - sc-398451 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PrP (G-12): sc-398451. Western blot analysis of PrP expression in NCI-H226 whole cell lysate (A) and human brain tissue extract (B).

PrP (H-8) - sc-393165 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PrP (H-8): sc-393165. Western blot analysis of PrP expression in human hippocampus tissue extract.

PrP (C-20) - sc-7693 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PrP (C-20) PE: sc-7693 PE. Intracellular FCM analysis of fixed and permeabilized BC<sub>3</sub>H1 cells. Black line histogram represents the isotype control, normal goat IgG: sc-3992.

PrP (FL-253) - sc-15312 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PrP (FL-253): sc-15312. Western blot analysis of PrP expression in rat brain (A) and mouse brain (B) tissue extracts.

PrP (AH6) - sc-69896 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PrP (AH6): sc-69896. Western blot analysis of PrP expression in mouse brain (A) and rat brain (B) tissue extracts.

PrP (6G3) - sc-52969 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
PrP (6G3): sc-52969. Western blot analysis of PrP expression in mouse brain tissue extract.

PrP (6D11) - sc-58581 from Santa Cruz Biotechnology

Prices $295.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
PrP (6D11): sc-58581. Western blot analysis of PrP expression in mouse brain tissue extract.

Anti-Prion protease resistant protein 27-30 antibody - ab187555 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of mouse lung tissue labelling Prion protease resistant protein 27-30 with ab187555 at 1/100. Magnification: 400x.

Anti-Prion protein PrP antibody - ab3531 from Abcam

Prices $372.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Prion protein PrP antibody - ab7303 from Abcam

Prices $373.00
Sizes 50 µl
Host Goat
Clonality Polyclonal

Anti-Prion protein PrP antibody - ab178545 from Abcam

Prices $376.00
Sizes 200 µl
Host Chicken
Clonality Polyclonal
Immunofluorescent analysis of cultured fibroblasts cells transiently transfected with a plasmid containing the Prion protein PrP cDNA, labeling Prion protein PrP with ab178545 at 1/1000 dilution.

Anti-Prion protein PrP antibody [EP1802Y] - ab52604 from Abcam

Prices $392.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1802Y
Anti-Prion protein PrP antibody [EP1802Y] (ab52604) at 1/10000 dilution + fetal brain lysate at 10 µgSecondaryHRP-labelled goat anti-rabbit at 1/2000 dilution

Anti-PRNP / PrP / Prion Antibody (clone V21-V) IHC-plus™ - LS-B10196 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Clone V21-V
Anti-PRNP / PrP / Prion antibody IHC staining of human small intestine, submucosal plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-PRNP / PrP / Prion Antibody (aa79-97) - LS-C85933 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Goat
Clonality Polyclonal

Anti-PRNP / PrP / Prion Antibody - LS-C103052 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-PRNP / PrP / Prion Antibody (C-Terminus) - LS-C92310 from LifeSpan Bioscience

Host Rabbit
Clonality Monoclonal

Anti-PRNP / PrP / Prion Antibody (C-Terminus) - LS-C121285 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-PRNP / PrP / Prion Antibody - LS-C122333 from LifeSpan Bioscience

Prices $620.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-PRNP / PrP / Prion Antibody - LS-C122334 from LifeSpan Bioscience

Prices $485.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal

Anti-PRNP / PrP / Prion Antibody (C-Terminus) - LS-C144597 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PRNP / PrP / Prion Antibody - LS-C124418 from LifeSpan Bioscience

Prices $875.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-PRNP / PrP / Prion Antibody (C-Terminus) - LS-C144598 from LifeSpan Bioscience

Prices $515.00
Sizes 25 µg
Host Rabbit
Clonality Polyclonal

Anti-PRNP / PrP / Prion Antibody (aa79-97) - LS-C191218 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-PRNP / PrP / Prion Antibody (aa142-148) - LS-C191219 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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