PRNP

Gene Symbol	PRNP
Entrez Gene	5621
Alt Symbol	ASCR, AltPrP, CD230, CJD, GSS, KURU, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, p27-30
Species	Human
Gene Type	protein-coding
Description	prion protein
Other Description	CD230 antigen|major prion protein|prion-related protein
Swissprots	Q96E70 Q9UP19 Q8TBG0 P78446 F7VJQ1 Q15221 O60489 Q15216 Q27H91 Q5QPB4 P04156
Accessions	AAB20521 AAB20522 AAB20523 AAB21334 AAB35416 AAB50648 AAB50649 AAB50777 AAB59442 AAB59443 AAC05365 AAC62750 AAC78725 AAD15012 AAD46098 AAO83635 AAO83636 AAR21603 ABD63004 ABL75508 ADD71057 ADO16981 CAA58442 DAA34790 EAX10449 EAX10450 F7VJQ1 P04156 AB300823 BAG32276 AB300824 BAG32277 AB300825 BAG32278 AB300826 BAG32279 AK090575 BAG52189 AK293312 BAG56832 AK295415 BAG58365 AK295943 BAG58727 AK312276 BAG35206 AW452130 AY008282 AAG21693 AY569456 AAS80162 BC012844 AAH12844 BC016809 BC022532 AAH22532 BG397054 BI669189 BP251427 BT019496 AAV38303 CR542039 CAG46836 CR542072 CAG46869 D00015 BAA00011 DA122620 DA297032 DB461478 DQ891318 ABM82244 DQ894502 ABM85428 M13667 AAA19664 M13899 AAA60182 X82545 CAA57895 NM_000311 NP_000302 NM_001080121 NP_001073590 NM_001080122 NP_001073591 NM_001080123 NP_001073592 NM_001271561 NP_001258490 NM_183079 NP_898902
Function	May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity). {ECO:0000250}.
Subcellular Location	Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of CU(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.
Tissue Specificity	Detected in brain homogenate, primary neurons, and peripheral blood mononuclear cells (at protein level). {ECO:0000269|PubMed:21478263}.
Top Pathways	Prion diseases

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Cow Prion protein PrP (mutated A144 V) full length protein - ab90589 from Abcam Category Protein Source E. coli Species Bovine

Cow Prion protein PrP (mutated F209 S) full length protein - ab90587 from Abcam Category Protein Source E. coli Species Bovine

Cow Prion protein PrP (mutated Q228 R) full length protein - ab90588 from Abcam Category Protein Source E. coli Species Bovine

Cow Prion protein PrP full length protein - ab753 from Abcam Category Protein Prices $343.00 Sizes 100 µg Source E. coli Species Bovine

Hamster Prion protein PrP full length protein - ab90483 from Abcam Category Protein Prices $188.00 Sizes 5 µg Source E. coli Species Hamster

Hamster Prion protein PrP protein fragment - ab90482 from Abcam Category Protein Prices $235.00 Sizes 50 µg Source E. coli Species Hamster

Human Prion protein PrP (mutated T194 A) full length protein - ab90586 from Abcam Category Protein Source E. coli Species Human

Human Prion protein PrP full length protein - ab140567 from Abcam Category Protein Source E. coli Species Human

Human Prion protein PrP peptide - ab49415 from Abcam Category Peptide Species Human

Human Prion protein PrP peptide - ab50457 from Abcam Category Peptide Species Human

Mouse Prion protein PrP full length protein - ab74056 from Abcam Category Protein Source E. coli Species Mouse

Prion protein PrP peptide - ab4908 from Abcam Category Peptide

Prion protein PrP peptide - ab5845 from Abcam Category Peptide

Sheep Prion protein PrP full length protein - ab90464 from Abcam Category Protein Source E. coli Species Sheep

Sheep Prion protein PrP protein fragment - ab74200 from Abcam Category Protein Source E. coli Species Sheep

PRNP / PrP / Prion Antibody Blocking Peptide - LS-E23050 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Prion protein Recombinant Protein - H00005621-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 2 µg Species Human

Prion protein Recombinant Protein - H00005621-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 2 µg Species Human

Recombinant Human Prion protein Protein - NBP2-23360 from Novus Biologicals Category Protein Prices $269.00 Sizes 20 µg Source E.coli Species Human

Prion Protein (PrP) (143-153) blocking peptide - GTX89339-PEP from GeneTex Category Protein Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

SYNTHETIC Human PRION Protein (OPSA10588) - OPSA10588 from Aviva Systems Biology Category Protein Prices $155.00 Sizes 50 µg Species Human

Human PrP protein - orb49527 from Biorbyt Category Protein Prices $306.00, $680.00, $2,321.00, $3,281.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human PRNP protein - orb169078 from Biorbyt Category Protein Prices $170.00, $289.00, $1,139.00 Sizes 2 μg, 10 μg, 100 μg Species Human

PRNP protein (His tag) - 80R-2717 from Fitzgerald Category Protein Prices $270.00 Sizes 20 µg Source E.coli

Human Prion Protein Protein - abx068667 from Abbexa Category Protein Source E.coli Species Human

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