| Gene Symbol |
JAK1
|
| Entrez Gene |
3716
|
| Alt Symbol |
JAK1A, JAK1B, JTK3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Janus kinase 1
|
| Other Description |
tyrosine-protein kinase JAK1
|
| Swissprots |
P23458 Q9UD26 Q59GQ2
|
| Accessions |
CBG22571 EAX06547 EAX06548 P23458 AB209057 BAD92294 AB219242 BAE02826 AK128375 AK314257 BC009079 BC023604 AAH23604 BC062431 AAH62431 BC111401 AAI11402 BC132729 AAI32730 BX647675 BX648044 HQ628631 AER93381 M64174 AAA36527 XM_005270841 XP_005270898 XM_006710624 XP_006710687 XM_011541395 XP_011539697 NM_002227 NP_002218
|
| Function |
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor. {ECO:0000269|PubMed:11909529}.
|
| Subcellular Location |
Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated.
|
| Tissue Specificity |
Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue. {ECO:0000269|PubMed:7896447}.
|
| Top Pathways |
Viral carcinogenesis, Pancreatic cancer, Signaling pathways regulating pluripotency of stem cells, Osteoclast differentiation, Epstein-Barr virus infection
|
![Western Blot: JAK1 Lysate [NBL1-12093] - Western Blot experiments. Left-Control; Right -Over-expression Lysate for JAK1](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/13249_JAK1%2520Lysate-Western%2520Blot-NBL1-12093-img0001.jpg)