JAK1

Gene Symbol	JAK1
Entrez Gene	3716
Alt Symbol	JAK1A, JAK1B, JTK3
Species	Human
Gene Type	protein-coding
Description	Janus kinase 1
Other Description	tyrosine-protein kinase JAK1
Swissprots	P23458 Q9UD26 Q59GQ2
Accessions	CBG22571 EAX06547 EAX06548 P23458 AB209057 BAD92294 AB219242 BAE02826 AK128375 AK314257 BC009079 BC023604 AAH23604 BC062431 AAH62431 BC111401 AAI11402 BC132729 AAI32730 BX647675 BX648044 HQ628631 AER93381 M64174 AAA36527 XM_005270841 XP_005270898 XM_006710624 XP_006710687 XM_011541395 XP_011539697 NM_002227 NP_002218
Function	Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor. {ECO:0000269|PubMed:11909529}.
Subcellular Location	Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated.
Tissue Specificity	Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue. {ECO:0000269|PubMed:7896447}.
Top Pathways	Viral carcinogenesis, Pancreatic cancer, Signaling pathways regulating pluripotency of stem cells, Osteoclast differentiation, Epstein-Barr virus infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

JAK1 CRISPR/Cas9 KO Plasmid (h) - sc-400439 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

JAK1 HDR Plasmid (h) - sc-400439-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

JAK1 Double Nickase Plasmid (h) - sc-400439-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

JAK1 Double Nickase Plasmid (h2) - sc-400439-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

JAK1 CRISPR Activation Plasmid (h) - sc-400439-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

JAK1 CRISPR Activation Plasmid (h2) - sc-400439-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

JAK1 Lentiviral Activation Particles (h) - sc-400439-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

JAK1 Lentiviral Activation Particles (h2) - sc-400439-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

JAK1 siRNA (h) - sc-35719 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

JAK1 shRNA Plasmid (h) - sc-35719-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

JAK1 shRNA (h) Lentiviral Particles - sc-35719-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Jak1 RNAi - H00003716-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU084871 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1005 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1003 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1004 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1359 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1359 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

JAK1 siRNA (Human) - CRH2502 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

JAK1, siRNA - MBS8205902 from MyBioSource Category siRNA Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human Jak1 (NM_002227.2) - SHH321911 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human JAK1(NM_002227.2) - SHL185222 from Creative biogene Category siRNA Species Reactivities Human

Human JAK1 siRNA - orb263004 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

JAK1 shRNA Plasmid (Human) - CHH2502 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

JAK1 miRNA 3'UTR clone - MiUTR1H-05059 from Creative biogene Species Reactivities Human

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