| Gene Symbol |
CRLF2
|
| Entrez Gene |
64109
|
| Alt Symbol |
CRL2, CRLF2Y, TSLPR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytokine receptor-like factor 2
|
| Other Description |
IL-XR|TSLP receptor|cytokine receptor CRL2 precusor|thymic stromal lymphopoietin protein receptor|thymic stromal-derived lymphopoietin receptor
|
| Swissprots |
Q9H5R3 Q5G7M1 Q9HC73 J3QKD1
|
| Accessions |
CAL40435 CAL44819 CAV28560 CAX87028 CAZ78684 CBX74362 CBX78819 EAW98672 Q9HC73 AB052639 BAB60717 AF142570 AAG27923 AF338733 AAK60618 AK026800 BAB15557 AK223303 BAD97023 AK225583 AY775789 AAW66851 BC160055 AAI60055 XM_011545634 XP_011543936 XM_011545635 XP_011543937 XM_011546181 XP_011544483 XM_011546182 XP_011544484 NM_001012288 NP_001012288 NM_022148 NP_071431 NR_110830
|
| Function |
Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system. {ECO:0000250, ECO:0000269|PubMed:11418668}.
|
| Subcellular Location |
Isoform 1: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed in heart, skeletal muscle, kidney and adult and fetal liver. Primarily expressed in dendrites and monocytes. Weakly expressed in T-cells.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
|