| Gene Symbol | pi4k2a |
|---|---|
| Entrez Gene | 406667 |
| Alt Symbol | pi4kII alpha, pi4kii, wu:fc84f05, zgc:63646 |
| Species | Zebrafish |
| Gene Type | protein-coding |
| Description | phosphatidylinositol 4-kinase type 2 alpha |
| Other Description | PI4KII-alpha|phosphatidylinositol 4-kinase II alpha|phosphatidylinositol 4-kinase type 2-alpha|phosphatidylinositol 4-kinase type II|phosphatidylinositol 4-kinase type II-alpha |
| Swissprots | Q52PF3 Q6PE18 A5PF25 |
| Accessions | Q6PE18 AY929290 AAY16565 AY989909 AAX89135 BC058342 AAH58342 NM_213358 NP_998523 |
| Function | Membrane-bound phosphatidylinositol-4 kinase (PI4- kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). {ECO:0000250|UniProtKB:Q9BTU6}. |
| Subcellular Location | Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q9BTU6}; Lipid-anchor {ECO:0000250|UniProtKB:Q9BTU6}. Membrane raft {ECO:0000250|UniProtKB:Q9BTU6}. Cell projection, dendrite {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Mitochondrion {ECO:0000250}. Endosome {ECO:0000250|UniProtKB:Q9BTU6}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9BTU6}. |
| Top Pathways | Inositol phosphate metabolism, Phosphatidylinositol signaling system |