| Gene Symbol |
Grik3
|
| Entrez Gene |
14807
|
| Alt Symbol |
9630027E11, GluK3, GluR7-3, Glur-7, Glur7
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
glutamate receptor, ionotropic, kainate 3
|
| Other Description |
glutamate receptor 7|glutamate receptor ionotropic, kainate 3
|
| Swissprots |
B1AS29 Q9JIA8 Q17R20
|
| Accessions |
B1AS29 AF245444 AAF90049 AK036014 BC118004 AAI18005 BC160379 AAI60379 BI133765 BM899529 BM933834 BM944246 BQ178996 BU611628 CD802840 CD804292 CF744155 CF745811 CJ149719 CX563583 XM_006502772 XP_006502835 NM_001081097 NP_001074566
|
| Function |
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Detected in whole brain, cerebellum, brain cortex and hippocampus. {ECO:0000269|PubMed:11124978}.
|
| Top Pathways |
Glutamatergic synapse, Neuroactive ligand-receptor interaction
|