Gene Symbol | Grik3 |
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Entrez Gene | 14807 |
Alt Symbol | 9630027E11, GluK3, GluR7-3, Glur-7, Glur7 |
Species | Mouse |
Gene Type | protein-coding |
Description | glutamate receptor, ionotropic, kainate 3 |
Other Description | glutamate receptor 7|glutamate receptor ionotropic, kainate 3 |
Swissprots | B1AS29 Q9JIA8 Q17R20 |
Accessions | B1AS29 AF245444 AAF90049 AK036014 BC118004 AAI18005 BC160379 AAI60379 BI133765 BM899529 BM933834 BM944246 BQ178996 BU611628 CD802840 CD804292 CF744155 CF745811 CJ149719 CX563583 XM_006502772 XP_006502835 NM_001081097 NP_001074566 |
Function | Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Tissue Specificity | Detected in whole brain, cerebellum, brain cortex and hippocampus. {ECO:0000269|PubMed:11124978}. |
Top Pathways | Glutamatergic synapse, Neuroactive ligand-receptor interaction |
GluR-7 CRISPR/Cas9 KO Plasmid (m) - sc-420686 from Santa Cruz Biotechnology
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GluR-7 HDR Plasmid (m) - sc-420686-HDR from Santa Cruz Biotechnology
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GluR-7 Double Nickase Plasmid (m) - sc-420686-NIC from Santa Cruz Biotechnology
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GluR-7 Double Nickase Plasmid (m2) - sc-420686-NIC-2 from Santa Cruz Biotechnology
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GluR-7 CRISPR Activation Plasmid (m) - sc-420686-ACT from Santa Cruz Biotechnology
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GluR-7 CRISPR Activation Plasmid (m2) - sc-420686-ACT-2 from Santa Cruz Biotechnology
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GluR-7 Lentiviral Activation Particles (m) - sc-420686-LAC from Santa Cruz Biotechnology
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GluR-7 Lentiviral Activation Particles (m2) - sc-420686-LAC-2 from Santa Cruz Biotechnology
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GluR-7 siRNA (m) - sc-42490 from Santa Cruz Biotechnology
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GluR-7 shRNA Plasmid (m) - sc-42490-SH from Santa Cruz Biotechnology
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GluR-7 shRNA (m) Lentiviral Particles - sc-42490-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU167961 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN32841 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND32841 from Sigma-Aldrich
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GRIK3 siRNA (Mouse) - CRM1690 from Cohesion Biosciences
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GRIK3 - MBS8210595 from MyBioSource
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shRNA set against Mouse GRIK3 (NM_001081097.2) - SHH307854 from Creative biogene
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shRNA set against Mouse Grik3(NM_001081097.2) - SHH104429 from Creative biogene
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Mouse GRIK3 siRNA - orb281166 from Biorbyt
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GRIK3 shRNA Plasmid (Mouse) - CHM1690 from Cohesion Biosciences
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GRIK3 miRNA 3'UTR clone - MiUTR1M-05377 from Creative biogene
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