| Gene Symbol |
RC3H1
|
| Entrez Gene |
149041
|
| Alt Symbol |
RNF198, ROQUIN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger and CCCH-type domains 1
|
| Other Description |
RING finger and C3H zinc finger protein 1|RING finger and CCCH-type zinc finger domain-containing protein 1|RING finger protein 198|probable E3 ubiquitin-protein ligase Roquin|roquin-1
|
| Swissprots |
Q5W180 Q5W181 Q5TC82 B3KVK1 Q8N9V1 Q8IVE6
|
| Accessions |
EAW90972 Q5TC82 AB095945 BAC23121 AK093501 BAC04186 AK122948 BAG53813 AY726570 BC136784 AAI36785 BC144408 AAI44409 BX537597 XM_005244921 XP_005244978 XM_011509230 XP_011507532 XM_011509231 XP_011507533 NM_001300850 NP_001287779 NM_001300851 NP_001287780 NM_001300852 NP_001287781 NM_172071 NP_742068
|
| Function |
Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity (By similarity). In resting or LPS- stimulated macrophages, controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, P-body {ECO:0000250}. Note=During stress, such as that induced by arsenite, localizes to cytosolic stress granules. {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed. Expressed at higher level in cerebellum, spleen, ovary and liver. {ECO:0000269|Ref.3}.
|