| Gene Symbol | Notch4 |
|---|---|
| Entrez Gene | 18132 |
| Alt Symbol | Int-3, Int3, N4 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | notch 4 |
| Other Description | Notch gene homolog 4|neurogenic locus notch homolog protein 4 |
| Swissprots | Q62389 Q9R1X0 Q9R1W9 O88316 Q62390 O35442 P31695 O88314 |
| Accessions | AAB82004 CAM18615 EDL26808 EDL26809 EDL26810 EDL26811 EDL26812 P31695 AK143484 AK166261 AK166493 BC138044 AAI38045 BC145114 M80456 AAB38377 XM_006523798 XP_006523861 XM_006525349 XP_006525412 XR_385298 XR_385939 NM_010929 NP_035059 |
| Function | Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May regulate branching morphogenesis in the developing vascular system. {ECO:0000250, ECO:0000269|PubMed:11344305}. |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Highly expressed in lung, moderately in heart kidney, and at lower levels in the ovary and skeletal muscle. A very low expression is seen in the brain, intestine, liver and testis. |
| Top Pathways | Notch signaling pathway, MicroRNAs in cancer, Dorso-ventral axis formation |
Recombinant Mouse Neurogenic locus notch homolog protein 4(Notch4) ,partial - CSB-YP015953MO CSB-EP015953MO CSB-BP015953MO CSB-MP015953MO from Cusabio
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Neurogenic locus notch homolog protein 4 (Notch4), partial, Recombinant Protein - MBS953792 from MyBioSource
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