| Gene Symbol | Ext2 |
|---|---|
| Entrez Gene | 3772101 |
| Alt Symbol | BcDNA:GH02288, CG33038, CG8433, DEXT2, DExt2, Dmel\CG8433, Sotv, sotv |
| Species | Drosophila |
| Gene Type | protein-coding |
| Description | CG8433 gene product from transcript CG8433-RB |
| Other Description | CG8433-PB|Ext2-PB|sister of tout-velu|sister-of-tout-velu |
| Swissprots | Q9Y169 |
| Accessions | AAO41379 Q9Y169 AF145598 AAD38573 BT003544 AAO39548 NM_166150 NP_725536 |
| Function | Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N- acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. Plays a central role in diffusion of morphogens hedgehog (hh), wingless (wg) and Decapentaplegic (dpp) via its role in heparan sulfate proteoglycans (HSPGs) biosynthesis, HSPGs being required for movement of Hh, Dpp and wg morphogens. {ECO:0000269|PubMed:14645127, ECO:0000269|PubMed:14998928, ECO:0000269|PubMed:15056609}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000269|PubMed:23720043}; Single- pass type II membrane protein {ECO:0000269|PubMed:23720043}. Note=Localization to the Golgi may be regulated by rti. |
| Tissue Specificity | In wing imaginal disk, it is ubiquitously expressed. {ECO:0000269|PubMed:14645127}. |
| Top Pathways | Glycosaminoglycan biosynthesis - heparan sulfate / heparin |