| Gene Symbol | vinA |
|---|---|
| Entrez Gene | 8625369 |
| Alt Symbol | DDBDRAFT_0186762, DDBDRAFT_0232320, DDB_0186762, DDB_0232320 |
| Species | Dictyostelium discoideum |
| Gene Type | protein-coding |
| Description | vinculin A |
| Other Description | - |
| Swissprots | Q54MH2 |
| Accessions | EAL64504 XM_632926 XP_638018 |
| Function | Involved in cell adhesion. Thought to play an important role in cytokinesis B, probably by providing substrate adhesion and traction forces. Required to organize and polarize the tip epithelium during cytokinesis. Required for the normal distribution of myosin in the tip epithelium. Involved in the localization of ctxA, ctxB, dcsA, exoc6 and rgaA. Thought to form a complex with ctxA, ctxB, and rgaA which regulates myosin accumulation to the apical plasma membrane. {ECO:0000269|PubMed:19065153, ECO:0000269|PubMed:21393547, ECO:0000269|PubMed:22902739}. |
| Subcellular Location | Cytoplasm, cell cortex. Cell junction. Note=Localized during interphase over the cell basal surface with levels decreasing at the basal surface when cells enter the mitotic phase. At this time, there is intense localization along the polar edges. Also found at cell-cell contacts in the slug and fruiting body and in columnar cells of the tip epithelium. |
| Tissue Specificity | Epithelium. {ECO:0000269|PubMed:21393547}. |