| Gene Symbol | TTC5 |
|---|---|
| Entrez Gene | 91875 |
| Alt Symbol | Strap |
| Species | Human |
| Gene Type | protein-coding |
| Description | tetratricopeptide repeat domain 5 |
| Other Description | TPR repeat protein 5|stress-responsive activator of p300|tetratricopeptide repeat protein 5 |
| Swissprots | A8MQ18 Q96HF9 Q8N0Z6 |
| Accessions | CAF86668 EAW66480 EAW66481 EAW66482 Q8N0Z6 AK074553 BAC11056 BC008647 AAH08647 BC030822 AAH30822 BC053538 AAH53538 BM998414 BX248066 CAD62359 BX640732 CAE45848 BX648584 DB051711 EU832467 ACE87639 HQ447721 ADQ32206 NM_138376 NP_612385 |
| Function | Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus. Cytoplasm. Note=Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm. {ECO:0000250}. |
tetratricopeptide repeat domain 5, ELISA Kit - MBS9336838 from MyBioSource
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Human TTC5 ELISA Kit - E037887 from Biobool
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