| Gene Symbol |
TTC5
|
| Entrez Gene |
91875
|
| Alt Symbol |
Strap
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tetratricopeptide repeat domain 5
|
| Other Description |
TPR repeat protein 5|stress-responsive activator of p300|tetratricopeptide repeat protein 5
|
| Swissprots |
A8MQ18 Q96HF9 Q8N0Z6
|
| Accessions |
CAF86668 EAW66480 EAW66481 EAW66482 Q8N0Z6 AK074553 BAC11056 BC008647 AAH08647 BC030822 AAH30822 BC053538 AAH53538 BM998414 BX248066 CAD62359 BX640732 CAE45848 BX648584 DB051711 EU832467 ACE87639 HQ447721 ADQ32206 NM_138376 NP_612385
|
| Function |
Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm. {ECO:0000250}.
|