| Gene Symbol | CELE_F35H12.3 |
|---|---|
| Entrez Gene | 180441 |
| Alt Symbol | - |
| Species | C. elegans |
| Gene Type | protein-coding |
| Description | SEL-12 |
| Other Description | - |
| Swissprots | P52166 Q20076 Q9U9C7 |
| Accessions | CCD70617 P52166 AF171064 AAD50991 NM_075774 NP_508175 |
| Function | Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Provides the major presenilin function compared to hop-1 and spe-4. Required cell-autonomously for correct neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis. Required for mesodermal patterning of muscle function. {ECO:0000269|PubMed:10917532, ECO:0000269|PubMed:12413907}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Tissue Specificity | Expressed in most neurons. {ECO:0000269|PubMed:10917532}. |
| Top Pathways | Wnt signaling pathway, Notch signaling pathway |