| Gene Symbol |
DGAT1
|
| Entrez Gene |
8694
|
| Alt Symbol |
ARAT, ARGP1, DGAT, DIAR7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
diacylglycerol O-acyltransferase 1
|
| Other Description |
ACAT related gene product 1|acyl coenzyme A:cholesterol acyltransferase related gene 1|acyl-CoA retinol O-fatty-acyltransferase|acyl-CoA:diacylglycerol acyltransferase|diglyceride acyltransferase
|
| Swissprots |
B2RWQ2 Q96BB8 O75907 D3DWL6
|
| Accessions |
EAW82127 EAW82128 EAW82129 EAW82130 O75907 AB057815 BAC66170 AF059202 AAC63997 BC006263 AAH06263 BC015762 AAH15762 BC023565 AAH23565 BC106084 AAI06085 BC150649 AAI50650 BI907285 CK300256 DQ892286 ABM83212 DQ895486 ABM86412 HY016503 XM_011517356 XP_011515658 NM_012079 NP_036211
|
| Function |
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. {ECO:0000269|PubMed:16214399, ECO:0000269|PubMed:9756920}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Top Pathways |
Fat digestion and absorption, Glycerolipid metabolism, Retinol metabolism
|