Gene Symbol | OLAH |
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Entrez Gene | 55301 |
Alt Symbol | AURA1, SAST, THEDC1 |
Species | Human |
Gene Type | protein-coding |
Description | oleoyl-ACP hydrolase |
Other Description | S-acyl fatty acid synthase thioesterase, medium chain|augmented in rheumatoid arthritis 1|thioesterase II|thioesterase domain containing 1|thioesterase domain-containing protein 1 |
Swissprots | Q9NUW1 Q5VUB6 Q9NV23 |
Accessions | CAE89822 EAW86244 EAW86245 Q9NV23 AK001844 BAA91937 AK001968 BAA92007 BC050372 AAH50372 BG281536 BG722790 BI830605 BR000403 FAA00320 HQ448637 ADQ33115 XM_006717456 XP_006717519 NM_001039702 NP_001034791 NM_018324 NP_060794 |
Function | In fatty acid biosynthesis chain termination and release of the free fatty acid product is achieved by hydrolysis of the thio ester by a thioesterase I, a component of the fatty acid synthetase complex. The chain length of the released fatty acid is usually C16. However, in the mammary glands of non-ruminant mammals, and in the uropygial gland of certain waterfowl there exists a second thioesterase which releases medium-chain length fatty acids (C8 to C2) (By similarity). {ECO:0000250}. |
Tissue Specificity | Isoform 2 is up-regulated in bone marrow- derived mononuclear cells of rheumatoid arthritis patients. {ECO:0000269|PubMed:17082220}. |
Top Pathways | Fatty acid biosynthesis |
AURA1 CRISPR/Cas9 KO Plasmid (h) - sc-417787 from Santa Cruz Biotechnology
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AURA1 HDR Plasmid (h) - sc-417787-HDR from Santa Cruz Biotechnology
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AURA1 Double Nickase Plasmid (h) - sc-417787-NIC from Santa Cruz Biotechnology
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AURA1 Double Nickase Plasmid (h2) - sc-417787-NIC-2 from Santa Cruz Biotechnology
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AURA1 CRISPR Activation Plasmid (h) - sc-417787-ACT from Santa Cruz Biotechnology
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AURA1 CRISPR Activation Plasmid (h2) - sc-417787-ACT-2 from Santa Cruz Biotechnology
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AURA1 Lentiviral Activation Particles (h) - sc-417787-LAC from Santa Cruz Biotechnology
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AURA1 Lentiviral Activation Particles (h2) - sc-417787-LAC-2 from Santa Cruz Biotechnology
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AURA1 siRNA (h) - sc-90654 from Santa Cruz Biotechnology
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AURA1 shRNA Plasmid (h) - sc-90654-SH from Santa Cruz Biotechnology
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AURA1 shRNA (h) Lentiviral Particles - sc-90654-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU058831 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15713 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15713 from Sigma-Aldrich
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OLAH siRNA (Human) - CRJ0640 from Cohesion Biosciences
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shRNA set against Human OLAH (NM_018324.2) - SHH357604 from Creative biogene
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Human OLAH siRNA - orb271141 from Biorbyt
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OLAH shRNA Plasmid (Human) - CHJ0640 from Cohesion Biosciences
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OLAH miRNA 3'UTR clone - MiUTR4H-TG06234 from Creative biogene
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