Gene Symbol | NT5M |
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Entrez Gene | 56953 |
Alt Symbol | dNT-2, dNT2, mdN |
Species | Human |
Gene Type | protein-coding |
Description | 5',3'-nucleotidase, mitochondrial |
Other Description | 5' nucleotidase, mitochondrial|5'(3')-deoxyribonucleotidase, mitochondrial|5(3)-deoxyribonucleotidase|deoxy-5'-nucleotidase 2|mitochondrial 5' nucleotidase |
Swissprots | Q9NPB1 |
Accessions | CAB99251 EAW55710 Q9NPB1 AF210652 AAF87076 AL526346 BC035838 AAH35838 DQ323995 ABC88597 XM_005256731 XP_005256788 XM_005256732 XP_005256789 XM_005256733 XP_005256790 XM_005256734 XP_005256791 XM_005256737 XP_005256794 XM_011523961 XP_011522263 XM_011523962 XP_011522264 XM_011523963 XP_011522265 XM_011523964 XP_011522266 XM_011523965 XP_011522267 XM_011523966 XP_011522268 XM_011523967 XP_011522269 NM_020201 NP_064586 |
Function | Dephosphorylates specifically the 5' and 2'(3')- phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP. {ECO:0000269|PubMed:10899995}. |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:10899995}. |
Tissue Specificity | Highly expressed in heart, brain and skeletal muscle. Detected at very low levels in kidney and pancreas. {ECO:0000269|PubMed:10899995}. |
Top Pathways | Purine metabolism, Nicotinate and nicotinamide metabolism, Pyrimidine metabolism |
dNT-2 (E-20) - sc-18020 from Santa Cruz Biotechnology
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Anti-NT5M antibody - ab57518 from Abcam
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Anti-NT5M Antibody (aa35-84) - LS-C116674 from LifeSpan Bioscience
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Anti-NT5M Antibody (aa143-192) - LS-C112044 from LifeSpan Bioscience
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NT5M Antibody - NBP1-54684 from Novus Biologicals
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NT5M Antibody - NBP1-54683 from Novus Biologicals
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NT5M Antibody - NBP1-92203 from Novus Biologicals
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NT5M Antibody (3E2) - H00056953-M02 from Novus Biologicals
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Anti-NT5M, (N-terminal) antibody produced in rabbit - SAB2106105 from Sigma-Aldrich
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Anti-NT5M antibody produced in rabbit - HPA043777 from Sigma-Aldrich
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Anti-NT5M antibody produced in rabbit - SAB2106106 from Sigma-Aldrich
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Monoclonal Anti-NT5M antibody produced in mouse - WH0056953M2 from Sigma-Aldrich
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NT5M antibody - N-terminal region (ARP57370_P050) - ARP57370_P050 from Aviva Systems Biology
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NT5M antibody - middle region (ARP57371_P050) - ARP57371_P050 from Aviva Systems Biology
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NT5M antibody - 70R-2441 from Fitzgerald
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NT5M antibody - 70R-2440 from Fitzgerald
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NT5M antibody - 20765-1-AP from Acris Antibodies
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NT5M antibody - 20765-1-AP from Proteintech Group
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NT5M Antibody - GWB-MU798F from Genway Biotech
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NT5M Antibody - GWB-MU799G from Genway Biotech
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Anti-5',3'-nucleotidase, mitochondrial - 08A056953 from MP Biomedicals
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NT5M-Antibody-C-Term - AP21968b from Abgent, a WuXi AppTec company
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NT5M antibody - TA344802 from Acris Antibodies
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NT5M antibody - TA344803 from Acris Antibodies
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NT5M Antibody - SH-A14132 from Novatein Biosciences
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