| Gene Symbol |
NT5M
|
| Entrez Gene |
56953
|
| Alt Symbol |
dNT-2, dNT2, mdN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
5',3'-nucleotidase, mitochondrial
|
| Other Description |
5' nucleotidase, mitochondrial|5'(3')-deoxyribonucleotidase, mitochondrial|5(3)-deoxyribonucleotidase|deoxy-5'-nucleotidase 2|mitochondrial 5' nucleotidase
|
| Swissprots |
Q9NPB1
|
| Accessions |
CAB99251 EAW55710 Q9NPB1 AF210652 AAF87076 AL526346 BC035838 AAH35838 DQ323995 ABC88597 XM_005256731 XP_005256788 XM_005256732 XP_005256789 XM_005256733 XP_005256790 XM_005256734 XP_005256791 XM_005256737 XP_005256794 XM_011523961 XP_011522263 XM_011523962 XP_011522264 XM_011523963 XP_011522265 XM_011523964 XP_011522266 XM_011523965 XP_011522267 XM_011523966 XP_011522268 XM_011523967 XP_011522269 NM_020201 NP_064586
|
| Function |
Dephosphorylates specifically the 5' and 2'(3')- phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP. {ECO:0000269|PubMed:10899995}.
|
| Subcellular Location |
Mitochondrion {ECO:0000269|PubMed:10899995}.
|
| Tissue Specificity |
Highly expressed in heart, brain and skeletal muscle. Detected at very low levels in kidney and pancreas. {ECO:0000269|PubMed:10899995}.
|
| Top Pathways |
Purine metabolism, Nicotinate and nicotinamide metabolism, Pyrimidine metabolism
|