| Gene Symbol |
DEF6
|
| Entrez Gene |
50619
|
| Alt Symbol |
IBP, SLAT, SWAP70L
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
differentially expressed in FDCP 6 homolog (mouse)
|
| Other Description |
DEF-6|IRF4-binding protein|SWAP-70-like adaptor protein of T cells|differentially expressed in FDCP 6 homolog
|
| Swissprots |
Q86VF4 Q9H4E7
|
| Accessions |
EAX03821 EAX03822 EAX03823 EAX03824 Q9H4E7 AJ276095 CAC08450 AK093613 BAG52743 AK314756 BAG37294 AL110182 AY241694 AAO91767 BC007702 BC017504 BC168373 AAI68373 NM_022047 NP_071330
|
| Function |
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm. Cell membrane. Nucleus. Note=Recruited to the plasma membrane upon binding phosphatidylinositol 3,4,5-trisphosphate.
|
| Tissue Specificity |
Broadly expressed in the immune system and can be detected in T and B-cells. {ECO:0000269|PubMed:12651066}.
|
![Western Blot: DEF6 Overexpression Lysate (Adult Normal) [NBP2-06481] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DEF6.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10302_DEF6%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06481-img0001.jpg)