DEF6

Gene Symbol	DEF6
Entrez Gene	50619
Alt Symbol	IBP, SLAT, SWAP70L
Species	Human
Gene Type	protein-coding
Description	differentially expressed in FDCP 6 homolog (mouse)
Other Description	DEF-6|IRF4-binding protein|SWAP-70-like adaptor protein of T cells|differentially expressed in FDCP 6 homolog
Swissprots	Q86VF4 Q9H4E7
Accessions	EAX03821 EAX03822 EAX03823 EAX03824 Q9H4E7 AJ276095 CAC08450 AK093613 BAG52743 AK314756 BAG37294 AL110182 AY241694 AAO91767 BC007702 BC017504 BC168373 AAI68373 NM_022047 NP_071330
Function	Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm. Cell membrane. Nucleus. Note=Recruited to the plasma membrane upon binding phosphatidylinositol 3,4,5-trisphosphate.
Tissue Specificity	Broadly expressed in the immune system and can be detected in T and B-cells. {ECO:0000269|PubMed:12651066}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DEF6 full length protein - ab153323 from Abcam Category Protein Source Wheat germ Species Human

DEF6-Antibody-C-term-Blocking-Peptide - BP16557b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DEF6 blocking peptide - GTX89758-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

DEF6 Peptide - AC21-0547-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

DEF6 - H00050619-P01-02 from Acris Antibodies Category Protein Prices $300.00 Sizes 2 µg Source in vitro transl. Species Human

DEF6 Peptide - 45-473P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

DEF6 fusion protein - Ag1925 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human DEF6, GST-tagged - DEF6-11923H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Differentially expressed in FDCP 6 homolog(DEF6) - CSB-YP884467HU CSB-EP884467HU CSB-BP884467HU CSB-MP884467HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

DEF6 - TP317877 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

IBP/DEF6, Peptide - MBS425424 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Pig, Bovine

Differentially expressed in FDCP 6 homolog (DEF6), Recombinant Protein - MBS1436459 from MyBioSource Category Protein Prices $1,425.00, $1,425.00, $1,655.00, $1,655.00, $2,415.00, $2,415.00, $2,860.00, $2,860.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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