DEF6

Gene Symbol	DEF6
Entrez Gene	50619
Alt Symbol	IBP, SLAT, SWAP70L
Species	Human
Gene Type	protein-coding
Description	differentially expressed in FDCP 6 homolog (mouse)
Other Description	DEF-6|IRF4-binding protein|SWAP-70-like adaptor protein of T cells|differentially expressed in FDCP 6 homolog
Swissprots	Q86VF4 Q9H4E7
Accessions	EAX03821 EAX03822 EAX03823 EAX03824 Q9H4E7 AJ276095 CAC08450 AK093613 BAG52743 AK314756 BAG37294 AL110182 AY241694 AAO91767 BC007702 BC017504 BC168373 AAI68373 NM_022047 NP_071330
Function	Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm. Cell membrane. Nucleus. Note=Recruited to the plasma membrane upon binding phosphatidylinositol 3,4,5-trisphosphate.
Tissue Specificity	Broadly expressed in the immune system and can be detected in T and B-cells. {ECO:0000269|PubMed:12651066}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DEF6 CRISPR/Cas9 KO Plasmid (h) - sc-405524 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

DEF6 HDR Plasmid (h) - sc-405524-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DEF6 Double Nickase Plasmid (h) - sc-405524-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DEF6 Double Nickase Plasmid (h2) - sc-405524-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DEF6 CRISPR Activation Plasmid (h) - sc-405524-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

DEF6 CRISPR Activation Plasmid (h2) - sc-405524-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

DEF6 Lentiviral Activation Particles (h) - sc-405524-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DEF6 Lentiviral Activation Particles (h2) - sc-405524-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DEF6 siRNA (h) - sc-105283 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

DEF6 shRNA Plasmid (h) - sc-105283-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

DEF6 shRNA (h) Lentiviral Particles - sc-105283-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU020461 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7081 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7081 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02866 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr02866

DEF6 siRNA (Human) - CRH9391 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

DEF6 RNAi - H00050619-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

DEF6 - MBS8237724 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

DEF6 CRISPR/Cas9 KO Plasmid (h2) - sc-405524-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

DEF6 HDR Plasmid (h2) - sc-405524-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human DEF6 (NM_022047.3) - SHH276305 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human DEF6(NM_022047.3) - SHG228067 from Creative biogene Category siRNA Species Reactivities Human

DEF6 shRNA Plasmid (Human) - CHH9391 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

DEF6 miRNA 3'UTR clone - MiUTR1H-02751 from Creative biogene Species Reactivities Human

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