| Gene Symbol | RFC1 |
|---|---|
| Entrez Gene | 5981 |
| Alt Symbol | A1, MHCBFB, PO-GA, RECC1, RFC, RFC140 |
| Species | Human |
| Gene Type | protein-coding |
| Description | replication factor C (activator 1) 1, 145kDa |
| Other Description | A1 140 kDa subunit|DNA-binding protein PO-GA|MHC binding factor, beta|RF-C 140 kDa subunit|activator 1 140 kDa subunit|activator 1 large subunit|activator 1 subunit 1|replication factor C 140 kDa subunit|replication factor C large subunit|replication factor C subunit 1|replication factor C1 |
| Swissprots | Q6PKU0 A8K6E7 Q86V46 Q5XKF5 P35251 Q86V41 |
| Accessions | AAS94325 EAW92922 EAW92923 EAW92924 P35251 AF040250 AAB99788 AJ564999 CAD92367 AK291612 BAF84301 BC010387 BC035297 AAH35297 BC051751 AAH51751 BC051786 AAH51786 DA336360 EU447003 ABZ92532 L23320 AAA16121 L24783 X69821 CAA49475 XM_011513730 XP_011512032 XM_011513731 XP_011512033 NM_001204747 NP_001191676 NM_002913 NP_002904 |
| Function | The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA. {ECO:0000269|PubMed:8999859}. |
| Subcellular Location | Nucleus. |
| Tissue Specificity | Wide tissue distribution. Undetectable in placental tissue. |
| Top Pathways | DNA replication, Mismatch repair, Nucleotide excision repair |