| Gene Symbol |
AEBP1
|
| Entrez Gene |
165
|
| Alt Symbol |
ACLP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
AE binding protein 1
|
| Other Description |
adipocyte enhancer-binding protein 1|aortic carboxypeptidase-like protein
|
| Swissprots |
Q59ER7 Q14113 Q7KZ79 Q6ZSC7 Q8IUX7
|
| Accessions |
EAL23768 EAW61119 Q8IUX7 AB209744 BAD92981 AF053944 AAC25585 AK090931 BAG52248 AK127541 BAC87026 AK296001 BAG58775 BC038588 AAH38588 BM672693 D86479 BAA13094 DB213495 XM_011515162 XP_011513464 NM_001129 NP_001120
|
| Function |
May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. {ECO:0000250}.
|
| Subcellular Location |
Isoform 1: Secreted {ECO:0000250}.
|
| Tissue Specificity |
Expressed in osteoblast and visceral fat. {ECO:0000269|PubMed:8920928}.
|