| Gene Symbol |
FPR1
|
| Entrez Gene |
2357
|
| Alt Symbol |
FMLP, FPR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
formyl peptide receptor 1
|
| Other Description |
N-formylpeptide chemoattractant receptor|fMLP receptor|fMet-Leu-Phe receptor
|
| Swissprots |
Q9NS48 Q86U52 P21462 Q7Z6A4 Q14939
|
| Accessions |
AAA16863 AAF87842 AAP58403 EAW72040 EAW72041 EAW72042 P21462 AK314935 BAG37441 BC005315 AAH05315 BQ016000 BT007429 AAP36097 CB993626 M37128 AAA36362 M60626 AAA35846 M60627 AAA35847 S49810 AAD14906 NM_001193306 NP_001180235 NM_002029 NP_002020
|
| Function |
High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system (PubMed:1712023, PubMed:10514456). {ECO:0000269|PubMed:10514456, ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:2161213, ECO:0000269|PubMed:2176894, ECO:0000303|PubMed:10514456, ECO:0000303|PubMed:1712023, ECO:0000303|PubMed:2161213, ECO:0000303|PubMed:2176894}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:2176894, ECO:0000305|PubMed:10514456}; Multi- pass membrane protein {ECO:0000255}.
|
| Tissue Specificity |
Neutrophils.
|
| Top Pathways |
Staphylococcus aureus infection, Rap1 signaling pathway, Neuroactive ligand-receptor interaction
|