Gene Symbol | FPR1 |
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Entrez Gene | 2357 |
Alt Symbol | FMLP, FPR |
Species | Human |
Gene Type | protein-coding |
Description | formyl peptide receptor 1 |
Other Description | N-formylpeptide chemoattractant receptor|fMLP receptor|fMet-Leu-Phe receptor |
Swissprots | Q9NS48 Q86U52 P21462 Q7Z6A4 Q14939 |
Accessions | AAA16863 AAF87842 AAP58403 EAW72040 EAW72041 EAW72042 P21462 AK314935 BAG37441 BC005315 AAH05315 BQ016000 BT007429 AAP36097 CB993626 M37128 AAA36362 M60626 AAA35846 M60627 AAA35847 S49810 AAD14906 NM_001193306 NP_001180235 NM_002029 NP_002020 |
Function | High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system (PubMed:1712023, PubMed:10514456). {ECO:0000269|PubMed:10514456, ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:2161213, ECO:0000269|PubMed:2176894, ECO:0000303|PubMed:10514456, ECO:0000303|PubMed:1712023, ECO:0000303|PubMed:2161213, ECO:0000303|PubMed:2176894}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:2176894, ECO:0000305|PubMed:10514456}; Multi- pass membrane protein {ECO:0000255}. |
Tissue Specificity | Neutrophils. |
Top Pathways | Staphylococcus aureus infection, Rap1 signaling pathway, Neuroactive ligand-receptor interaction |
FPR1 peptide - ab195246 from Abcam
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FPR1 peptide - ab156850 from Abcam
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FPR1 peptide - ab156855 from Abcam
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Human FPR1 full length protein - ab158465 from Abcam
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FPR1 / FPR Antibody Blocking Peptide - LS-E4835 from LifeSpan Bioscience
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FPR1 / FPR Antibody Blocking Peptide - LS-E28485 from LifeSpan Bioscience
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FPR1 / FPR Antibody Blocking Peptide - LS-E28484 from LifeSpan Bioscience
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FPR1 / FPR Antibody Blocking Peptide - LS-E28487 from LifeSpan Bioscience
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FPR1 / FPR Antibody Blocking Peptide - LS-E28486 from LifeSpan Bioscience
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FPR1 / FPR Antibody Blocking Peptide - LS-E23274 from LifeSpan Bioscience
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Recombinant Human FPR1 Protein - H00002357-P01 from Novus Biologicals
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FPR1 Peptide - NBP1-46324PEP from Novus Biologicals
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FPR1-Antibody-Center-Blocking-Peptide - BP17216c from Abgent, a WuXi AppTec company
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FPR1 Blocking Peptide - abx062634 from Abbexa
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FPR1 Blocking Peptide - abx062635 from Abbexa
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fMLP receptor - H00002357-G01 from Acris Antibodies
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fMLP receptor - H00002357-P01-10 from Acris Antibodies
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fMLP receptor - H00002357-P01-25 from Acris Antibodies
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fMLP receptor - H00002357-Q01-10 from Acris Antibodies
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fMLP receptor - H00002357-Q01-25 from Acris Antibodies
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FPR1 fusion protein - ag14063 from Proteintech Group
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Recombinant Human FPR1 - FPR1-26376TH from Creative Biomart
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Recombinant Human FPR1 - FPR1-27613TH from Creative Biomart
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Recombinant Human FPR1 - FPR1-31363TH from Creative Biomart
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Recombinant Formyl Peptide Receptor 1 (FPR1) - RPC948Hu01 from Uscn Life Science Inc.
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