PPAP2C
| Gene Symbol | PPAP2C |
|---|---|
| Entrez Gene | 8612 |
| Alt Symbol | LPP2, PAP-2c, PAP2-g |
| Species | Human |
| Gene Type | protein-coding |
| Description | phosphatidic acid phosphatase type 2C |
| Other Description | PAP2-gamma|PAP2c|lipid phosphate phosphohydrolase 2|phosphatidate phosphohydrolase type 2c|phosphatidic acid phosphatase 2c|phosphatidic acid phosphohydrolase type 2c|type-2 phosphatidic acid phosphatase-gamma |
| Swissprots | E9PAY8 A6NLV0 O43688 |
| Accessions | EAW61207 EAW61208 EAW61209 O43688 AA428937 AB209696 BAD92933 AF035959 AAC15968 AF047760 AAC32104 AF056083 AAC25666 BC002806 AAH02806 BE615792 BG831889 BM050291 BM982485 BT007021 AAP35667 HY160303 XM_011528396 XP_011526698 NM_003712 NP_003703 NM_177526 NP_803545 NM_177543 NP_808211 |
| Function | Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P. |
| Subcellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Specificity | Found mainly in brain, pancreas and placenta. |
| Top Pathways | Fc gamma R-mediated phagocytosis, Fat digestion and absorption, Choline metabolism in cancer, Ether lipid metabolism, Glycerolipid metabolism |
PAP-2c CRISPR/Cas9 KO Plasmid (h) - sc-411193 from Santa Cruz Biotechnology
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PAP-2c HDR Plasmid (h) - sc-411193-HDR from Santa Cruz Biotechnology
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PAP-2c Double Nickase Plasmid (h) - sc-411193-NIC from Santa Cruz Biotechnology
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PAP-2c Double Nickase Plasmid (h2) - sc-411193-NIC-2 from Santa Cruz Biotechnology
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PAP-2c CRISPR Activation Plasmid (h) - sc-411193-ACT from Santa Cruz Biotechnology
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PAP-2c CRISPR Activation Plasmid (h2) - sc-411193-ACT-2 from Santa Cruz Biotechnology
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PAP-2c Lentiviral Activation Particles (h) - sc-411193-LAC from Santa Cruz Biotechnology
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PAP-2c Lentiviral Activation Particles (h2) - sc-411193-LAC-2 from Santa Cruz Biotechnology
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PAP-2c siRNA (h) - sc-106353 from Santa Cruz Biotechnology
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PAP-2c shRNA Plasmid (h) - sc-106353-SH from Santa Cruz Biotechnology
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PAP-2c shRNA (h) Lentiviral Particles - sc-106353-V from Santa Cruz Biotechnology
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PPAP2C RNAi - H00008612-R02 from Novus Biologicals
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PPAP2C RNAi - H00008612-R03 from Novus Biologicals
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MISSION® esiRNA - EHU082671 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0444 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0442 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0443 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17198 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17198 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02593 from Sigma-Aldrich
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PPAP2C siRNA (Human) - CRH5658 from Cohesion Biosciences
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PPAP2C RNAi - H00008612-R01 from Novus Biologicals
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shRNA set against Human PPAP2C (NM_177543.1) - SHH380264 from Creative biogene
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shRNA set against Human PPAP2C(NM_003712.2) - SHR130484 from Creative biogene
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shRNA set against Human PPAP2C(NM_177543.1) - SHR130632 from Creative biogene
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