| Gene Symbol |
Grm6
|
| Entrez Gene |
24419
|
| Alt Symbol |
mGluR6
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
glutamate receptor, metabotropic 6
|
| Other Description |
metabotropic glutamate receptor 6
|
| Swissprots |
P35349
|
| Accessions |
EDM04284 P35349 AJ245718 CAC00714 D13963 BAA03066 XM_006246225 XP_006246287 XR_594657 NM_022920 NP_075209
|
| Function |
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision. {ECO:0000250, ECO:0000269|PubMed:8389366}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane. Detected at dendritic tips of bipolar cells (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Restricted expression in the inner nuclear layer of the retina. {ECO:0000269|PubMed:8389366}.
|
| Top Pathways |
Glutamatergic synapse, Neuroactive ligand-receptor interaction
|