Gene Symbol | BCAS3 |
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Entrez Gene | 54828 |
Alt Symbol | GAOB1, MAAB |
Species | Human |
Gene Type | protein-coding |
Description | breast carcinoma amplified sequence 3 |
Other Description | BCAS4/BCAS3 fusion|breast carcinoma amplified sequence 4/3 fusion protein|breast carcinoma-amplified sequence 3|metastasis associated antigen of breast cancer|protein Maab1 |
Swissprots | Q9H9Y9 Q8TDL9 Q17RM0 Q8WY55 Q8NDR8 Q9BVF0 Q8IXI6 Q9NXP4 Q9H957 Q9H6U6 Q8TDM1 Q6KF21 |
Accessions | EAW51410 EAW51411 EAW51412 EAW51413 EAW51414 EAW51415 EAW51416 Q9H6U6 AF260268 AAF70324 AF361219 AAL99632 AJ511332 CAD54076 AJ518105 CAD57723 AJ518836 CAD57724 AK000135 BAA90966 AK022526 BAB14078 AK023054 BAB14380 AK025510 BAB15156 AK125409 AK225757 AK304791 BAG65541 AK314744 BAG37284 AL831895 CAD38568 BC001250 AAH01250 BC013841 BC017390 AAH17390 BC029983 BC033220 BC036280 BC117275 AAI17276 BC143386 AAI43387 BC143387 AAI43388 BX648103 CA444316 DA188234 DA789232 XM_005257472 XP_005257529 XM_005257475 XP_005257532 XM_011524939 XP_011523241 XM_011524940 XP_011523242 XM_011524941 XP_011523243 XM_011524942 XP_011523244 XM_011524943 XP_011523245 XM_011524944 XP_011523246 XM_011524945 XP_011523247 XM_011524946 XP_011523248 XM_011524947 XP_011523249 XM_011524948 XP_011523250 XM_011524949 XP_011523251 XM_011524950 XP_011523252 XM_011524951 XP_011523253 XM_011524952 XP_011523254 XR_934493 NM_001099432 NP_001092902 NM_017679 NP_060149 |
Function | Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17505058}. Cytoplasm {ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:18030336}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8CCN5}. Note=Localizes in the cytoplasm in stationary cells. Translocates from the cytoplasm to the leading edge in motile cells. Colocalizes with microtubules and intermediate filaments in both stationary and motile cells (By similarity). Associates with chromatin. Recruited to estrogen receptor-induced promoters in a PELP1-dependent manner. {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058}. |
Tissue Specificity | Expressed in stomach, liver, lung, kidney, prostate, testis, thyroid gland, adrenal gland, brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leukocyte and mammary epithelial cells. Expressed in undifferentiated ES cells. Expressed in blood islands and nascent blood vessels derived from differentiated ES cells into embryoid bodies (BD). Expressed in endothelial cells. Not detected in brain. Expressed in brain tumors (at protein level). Expressed in brain. Highly expressed in breast cancers and in glioma cell lines. {ECO:0000269|PubMed:12378525, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:18030336}. |
Human BCAS3 full length protein - ab162853 from Abcam
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BCAS3 Antibody Blocking Peptide - LS-E3230 from LifeSpan Bioscience
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BCAS3 Antibody Blocking Peptide - LS-E30874 from LifeSpan Bioscience
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Recombinant Human Breast carcinoma amplified sequence 3 Protein - H00054828-P01 from Novus Biologicals
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Breast carcinoma amplified sequence 3 Blocking Peptide - NBP1-77125PEP from Novus Biologicals
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Breast carcinoma amplified sequence 3 Peptide - P0409 from Novus Biologicals
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BCAS3-Antibody-C-term-Blocking-Peptide - BP1437b from Abgent, a WuXi AppTec company
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BCAS3 / GAOB1 - H00054828-P01-10 from Acris Antibodies
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BCAS3 / GAOB1 - H00054828-P01-25 from Acris Antibodies
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BCAS3 Peptide - 5629P from ProSci
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BCAS3 fusion protein - ag0646 from Proteintech Group
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Recombinant Breast Carcinoma Amplified Sequence 3 (BCAS3) - RPF221Hu01 from Uscn Life Science Inc.
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Recombinant Breast Carcinoma Amplified Sequence 3 (BCAS3) - RPF221Hu01 from Cloud-clone
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Recombinant Human Breast carcinoma-amplified sequence 3(BCAS3) ,partial - CSB-YP872507HU CSB-EP872507HU CSB-BP872507HU CSB-MP872507HU from Cusabio
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Breast Carcinoma Amplified Sequence 3 Protein (Recombinant) - abx166992 from Abbexa
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BCAS3 / GAOB1 (transcript variant 2) - TP317085 from Acris Antibodies
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Breast carcinoma amplified sequence 3 Recombinant Protein Antigen - NBP2-14348PEP from Novus Biologicals
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BCAS3-Antibody-N-term-Blocking-Peptide - BP2738a from Abgent, a WuXi AppTec company
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BCAS3 Peptide, Human - M34GP01357H from Creative Peptides
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Recombinant Breast Carcinoma Amplified Sequence 3 (BCAS3) - RPU53186 from Biomatik
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BCAS3 Recombinant Protein (OPCD01593) - OPCD01593 from Aviva Systems Biology
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Breast carcinoma amplified sequence 3 Recombinant Protein Antigen - NBP2-58584PEP from Novus Biologicals
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Breast Carcinoma Amplified Sequence 3, Recombinant Protein - MBS2031194 from MyBioSource
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Breast carcinoma-amplified sequence 3 (BCAS3), partial, Recombinant Protein - MBS1370930 from MyBioSource
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Recombinant Human BCAS3 protein, His & T7-tagged - BCAS3-1417H from Creative Biomart
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