GRHL2

Gene Symbol GRHL2
Entrez Gene 79977
Alt Symbol BOM, DFNA28, ECTDS, TFCP2L3
Species Human
Gene Type protein-coding
Description grainyhead-like 2 (Drosophila)
Other Description brother of mammalian grainyhead|grainyhead-like protein 2 homolog|transcription factor CP2-like 3
Swissprots Q6ISB3 Q9H8B8 A1L303 Q6NT03
Accessions CBJ06470 EAW91833 EAW91834 Q6ISB3 AK002034 AK023844 BAB14699 AK292853 BAF85542 AK296817 BAG59390 AK310221 BC069618 AAH69618 BC069633 AAH69633 BC069638 AAH69638 BC129822 AAI29823 BC129823 AAI29824 XM_011517305 XP_011515607 XM_011517306 XP_011515608 XM_011517307 XP_011515609 NM_024915 NP_079191
Function Transcription factor playing an important role in primary neurulation and in epithelial development (PubMed:25152456). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (By similarity). During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. Up-regulates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at tight junctions (By similarity). Comprises an essential component of the transcriptional machinery that establishes appropriate expression levels of CLDN4 and CDH1 in different types of e
Subcellular Location Nucleus {ECO:0000269|PubMed:20938050, ECO:0000269|PubMed:25152456}. Membrane {ECO:0000269|PubMed:25152456}. Note=detected at cell-cell contact areas. {ECO:0000269|PubMed:25152456}.
Tissue Specificity Expressed in keratinocytes (at protein level). Highly expressed in placenta, prostate, brain and kidney. Lower- level expression in a variety of epithelial tissues such as thymus, lung, salivary gland, mammary gland and digestive tract. Expressed in the cochlear. {ECO:0000269|PubMed:12175488, ECO:0000269|PubMed:12393799, ECO:0000269|PubMed:20978075, ECO:0000269|PubMed:25152456}.

GRHL2 (A-15) - sc-87143 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GRHL2 (A-15): sc-87143. Western blot analysis of GRHL2 expression in BJAB (A), Ramos (B) and KNRK (C) nuclear extracts.

GRHL2 (N-14) - sc-87145 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-GRHL2 antibody - ab86611 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-GRHL2 antibody (ab86611) at 1 µg/ml (5% skim milk/ PBS buffer) + 721_B cell lysate at 10 µg with gel concentration: 12%SecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-GRHL2 antibody - ab88631 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-GRHL2 antibody (ab88631) at 1 µg/ml + A431 cell lysate at 50 µg/ml

Anti-GRHL2 antibody - ab155532 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GRHL2 antibody (ab155532) at 1/1000 dilutionLane 1 : NT2D1 whole cell lysateLane 2 : U87-MG whole cell lysateLysates/proteins at 30 µg per lane.

Anti-GRHL2 antibody - ab69052 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-GRHL2 antibody (ab69052) at 1/500 dilutionLane 1 : GRHL2 transfected 293T lysateLane 2 : Non-transfected 293T lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Anti-GRHL2 antibody - N-terminal - ab136682 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-GRHL2 antibody - N-terminal (ab136682) at 1 µg/ml + Rat Stomach lysate at 10 µg

Anti-GRHL2 Antibody (aa409-438) - LS-C159784 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
GRHL2 Antibody western blot of MDA-MB435 cell line lysates (35 ug/lane). The GRHL2 antibody detected the GRHL2 protein (arrow).

Anti-GRHL2 Antibody (C-Terminus) IHC-plus™ - LS-B3983 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-GRHL2 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3983 concentration 5 ug/ml.

Anti-GRHL2 Antibody (aa409-438, AP) - LS-C235976 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GRHL2 Antibody (aa409-438, Biotin) - LS-C235978 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GRHL2 Antibody (aa409-438, APC) - LS-C235977 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GRHL2 Antibody (aa409-438, PE) - LS-C235983 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GRHL2 Antibody (aa409-438, FITC) - LS-C235979 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GRHL2 Antibody (aa409-438, Azide-free, HRP) - LS-C249135 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GRHL2 Antibody - LS-C308115 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-GRHL2 Antibody (aa408-438) - LS-C321785 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GRHL2 Antibody (N-Terminus) - LS-C151216 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
GRHL2 antibody Western Blot of Rat Stomach.

GRHL2 Antibody - NBP1-80369 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: GRHL2 Antibody [NBP1-80369] - 721_B Cell Lysate 1ug/ml Gel Concentration 12%

GRHL2 Antibody - NBP1-88552 from Novus Biologicals

Prices $129.00, $419.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: GRHL2 Antibody [NBP1-88552] - Analysis in control (vector only transfected HEK293T lysate) and gRHL2 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

GRHL2 Antibody - H00079977-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: GRHL2 Antibody [H00079977-B01P] - Analysis of GRHL2 expression in A-431.

GRHL2 Antibody - NBP2-16745 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: GRHL2 Antibody [NBP2-16745] - Sample (30 ug of whole cell lysate) A: NT2D1 B: U87-MG 7. 5% SDS PAGE gel, diluted at 1:1000.

GRHL2 Antibody - H00079977-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Anti-GRHL2 antibody produced in rabbit - HPA004820 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-GRHL2: <B>Cat. No. HPA004820</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human placenta shows strong nuclear positivity in trophoblastic cells.

Anti-GRHL2 antibody produced in rabbit - SAB2103014 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-GRHL2: <B>Cat. No. SAB2103014</B>: Immunohistochemistry of GRHL2 in Human Brain tissue with GRHL2 antibody at 5.0 μg/mL.
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