| Gene Symbol |
GRHL2
|
| Entrez Gene |
79977
|
| Alt Symbol |
BOM, DFNA28, ECTDS, TFCP2L3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
grainyhead-like 2 (Drosophila)
|
| Other Description |
brother of mammalian grainyhead|grainyhead-like protein 2 homolog|transcription factor CP2-like 3
|
| Swissprots |
Q6ISB3 Q9H8B8 A1L303 Q6NT03
|
| Accessions |
CBJ06470 EAW91833 EAW91834 Q6ISB3 AK002034 AK023844 BAB14699 AK292853 BAF85542 AK296817 BAG59390 AK310221 BC069618 AAH69618 BC069633 AAH69633 BC069638 AAH69638 BC129822 AAI29823 BC129823 AAI29824 XM_011517305 XP_011515607 XM_011517306 XP_011515608 XM_011517307 XP_011515609 NM_024915 NP_079191
|
| Function |
Transcription factor playing an important role in primary neurulation and in epithelial development (PubMed:25152456). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (By similarity). During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. Up-regulates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at tight junctions (By similarity). Comprises an essential component of the transcriptional machinery that establishes appropriate expression levels of CLDN4 and CDH1 in different types of e
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:20938050, ECO:0000269|PubMed:25152456}. Membrane {ECO:0000269|PubMed:25152456}. Note=detected at cell-cell contact areas. {ECO:0000269|PubMed:25152456}.
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| Tissue Specificity |
Expressed in keratinocytes (at protein level). Highly expressed in placenta, prostate, brain and kidney. Lower- level expression in a variety of epithelial tissues such as thymus, lung, salivary gland, mammary gland and digestive tract. Expressed in the cochlear. {ECO:0000269|PubMed:12175488, ECO:0000269|PubMed:12393799, ECO:0000269|PubMed:20978075, ECO:0000269|PubMed:25152456}.
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