GRHL2

Gene Symbol GRHL2
Entrez Gene 79977
Alt Symbol BOM, DFNA28, ECTDS, TFCP2L3
Species Human
Gene Type protein-coding
Description grainyhead-like 2 (Drosophila)
Other Description brother of mammalian grainyhead|grainyhead-like protein 2 homolog|transcription factor CP2-like 3
Swissprots Q6ISB3 Q9H8B8 A1L303 Q6NT03
Accessions CBJ06470 EAW91833 EAW91834 Q6ISB3 AK002034 AK023844 BAB14699 AK292853 BAF85542 AK296817 BAG59390 AK310221 BC069618 AAH69618 BC069633 AAH69633 BC069638 AAH69638 BC129822 AAI29823 BC129823 AAI29824 XM_011517305 XP_011515607 XM_011517306 XP_011515608 XM_011517307 XP_011515609 NM_024915 NP_079191
Function Transcription factor playing an important role in primary neurulation and in epithelial development (PubMed:25152456). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (By similarity). During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. Up-regulates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at tight junctions (By similarity). Comprises an essential component of the transcriptional machinery that establishes appropriate expression levels of CLDN4 and CDH1 in different types of e
Subcellular Location Nucleus {ECO:0000269|PubMed:20938050, ECO:0000269|PubMed:25152456}. Membrane {ECO:0000269|PubMed:25152456}. Note=detected at cell-cell contact areas. {ECO:0000269|PubMed:25152456}.
Tissue Specificity Expressed in keratinocytes (at protein level). Highly expressed in placenta, prostate, brain and kidney. Lower- level expression in a variety of epithelial tissues such as thymus, lung, salivary gland, mammary gland and digestive tract. Expressed in the cochlear. {ECO:0000269|PubMed:12175488, ECO:0000269|PubMed:12393799, ECO:0000269|PubMed:20978075, ECO:0000269|PubMed:25152456}.

GRHL2 CRISPR/Cas9 KO Plasmid (h) - sc-408284 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GRHL2 HDR Plasmid (h) - sc-408284-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GRHL2 Double Nickase Plasmid (h) - sc-408284-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GRHL2 Double Nickase Plasmid (h2) - sc-408284-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GRHL2 CRISPR Activation Plasmid (h) - sc-408284-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GRHL2 CRISPR Activation Plasmid (h2) - sc-408284-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GRHL2 Lentiviral Activation Particles (h) - sc-408284-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GRHL2 Lentiviral Activation Particles (h2) - sc-408284-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GRHL2 siRNA (h) - sc-77606 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GRHL2 shRNA Plasmid (h) - sc-77606-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GRHL2 shRNA (h) Lentiviral Particles - sc-77606-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GRHL2 RNAi - H00079977-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU039141 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9672 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9672 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

GRHL2 siRNA (Human) - CRJ2703 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GRHL2 - MBS8237529 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human GRHL2 (NM_024915.3) - SHH307694 from Creative biogene

Category siRNA
Species Reactivities Human

GRHL2 shRNA Plasmid (Human) - CHJ2703 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

GRHL2 miRNA 3'UTR clone - MiUTR4H-TG03993 from Creative biogene

Species Reactivities Human
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