| Gene Symbol |
Trpm5
|
| Entrez Gene |
56843
|
| Alt Symbol |
9430099A16Rik, LTrpC-5, Ltrpc5, Mtr1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
transient receptor potential cation channel, subfamily M, member 5
|
| Other Description |
MLSN1- and TRP-related gene 1 protein|long transient receptor potential channel 5|long transient receptor potential-related channel 5|transient receptor potential cation channel subfamily M member 5|trpm5
|
| Swissprots |
Q3TU14 A3KN89 Q7TPL4 Q9EPM3 Q9EPM4 Q99NF9 Q9JJH7
|
| Accessions |
CAC19456 CAC19457 EDL18199 EDL18200 EDL18201 EDL18202 Q9JJH7 AB039952 BAA96877 AF228681 AAF98120 AJ271092 CAB94717 AK029187 AK035197 BAC28976 AK044908 AK161030 BAE36157 AY280364 AAP44476 AY280365 AAP44477 BC133712 AAI33713 CN668717 XM_006508645 XP_006508708 XM_006508646 XP_006508709 NM_020277 NP_064673
|
| Function |
Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent- specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5- triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius
|
| Subcellular Location |
Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TD43, ECO:0000255}.
|
| Tissue Specificity |
Strongly expressed in liver, heart, testis, brain and kidney. Detected in fetal liver, kidney, spleen, brain, heart and lung, and in adult skin, eyes, spleen, stomach, small intestine, colon, lung, bladder, pancreas and thymus. Biallelically expressed at all stages and tissues examined. Also expressed in subsets of taste receptor cells of the tongue, in olfactory sensory neurons of the main olfactory epithelium and in the vomeronasal organ. {ECO:0000269|PubMed:10903843, ECO:0000269|PubMed:12368808, ECO:0000269|PubMed:17267604, ECO:0000269|PubMed:17610722}.
|
| Top Pathways |
Taste transduction
|