| Gene Symbol |
ATP2B4
|
| Entrez Gene |
493
|
| Alt Symbol |
ATP2B2, MXRA1, PMCA4, PMCA4b, PMCA4x
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ATPase, Ca++ transporting, plasma membrane 4
|
| Other Description |
matrix-remodeling-associated protein 1|plasma membrane calcium-transporting ATPase 4|sarcolemmal calcium pump
|
| Swissprots |
Q16817 Q13455 B1APW5 B1APW6 Q13450 Q7Z3S1 Q13452 P23634
|
| Accessions |
EAW91483 EAW91484 EAW91485 EAW91486 EAW91487 P23634 AK026443 AK292458 BAF85147 AK307104 AL601702 AL706212 AM393326 CAL38204 AM393354 CAL38232 AW888226 BC062445 BC140774 AAI40775 BC150293 AAI50294 BF740130 BF985985 BX537444 CAD97686 BX537745 BX647701 CR749393 CAH18241 CR936708 DN997129 DQ201780 ABG24244 DQ201781 ABG24245 M25874 AAA50819 M83363 AAA36455 U42026 AAB17577 U42061 AAB17578 U42062 AAB17579 U42378 AAB17580 NM_001001396 NP_001001396 NM_001684 NP_001675
|
| Function |
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Isoform XB is the most abundant isoform and is expressed ubiquitously. Isoforms containing segment Z have only been detected in heart, while isoforms containing segment a have been found in heart, stomach and brain cortex.
|
| Top Pathways |
Calcium signaling pathway, Salivary secretion, Pancreatic secretion, Adrenergic signaling in cardiomyocytes, cGMP-PKG signaling pathway
|
![Western Blot: PMCA4 Overexpression Lysate (Adult Normal) [NBP2-10766] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PMCA4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6836_PMCA4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10766-img0001.jpg)