| Gene Symbol |
DXO
|
| Entrez Gene |
1797
|
| Alt Symbol |
DOM3L, DOM3Z, NG6, RAI1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
decapping exoribonuclease
|
| Other Description |
decapping and exoribonuclease protein|protein Dom3Z
|
| Swissprots |
Q6IPZ2 Q5ST60 O15004 B0UZ80 Q9NPK4 O77932 O78127 A2CER3 O78128
|
| Accessions |
AAB67983 CAB89305 CAB89306 EAX03558 EAX03559 EAX03560 EAX03561 EAX03562 EAX03563 EAX03564 EAX03565 O77932 AF059252 AAC78603 AF059253 AAC78604 AF059254 AAC78605 AK310107 BC009344 AAH09344 BC019083 AAH19083 BC030235 BC050618 BC058885 BC071651 DQ893041 ABM83967 DQ896284 ABM87283 XM_006715005 XP_006715068 XM_006715007 XP_006715070 XM_006725474 XP_006725537 XM_006725476 XP_006725539 XM_006725688 XP_006725751 XM_006725690 XP_006725753 XM_006725898 XP_006725961 XM_006725900 XP_006725963 XM_006725985 XP_006726048 XM_006725987 XP_006726050 XM_006726078 XP_006726141 XM_006726080 XP_006726143 XM_011547606 XP_011545908 XR_926081 XR_926082 XR_952207 XR_952208 XR_952941 XR_952942 XR_953003 XR_953004 XR_953077 XR_953078 NM_005510 NP_005501
|
| Function |
Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:21750099}.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:9799600}.
|