DXO

Gene Symbol	DXO
Entrez Gene	1797
Alt Symbol	DOM3L, DOM3Z, NG6, RAI1
Species	Human
Gene Type	protein-coding
Description	decapping exoribonuclease
Other Description	decapping and exoribonuclease protein|protein Dom3Z
Swissprots	Q6IPZ2 Q5ST60 O15004 B0UZ80 Q9NPK4 O77932 O78127 A2CER3 O78128
Accessions	AAB67983 CAB89305 CAB89306 EAX03558 EAX03559 EAX03560 EAX03561 EAX03562 EAX03563 EAX03564 EAX03565 O77932 AF059252 AAC78603 AF059253 AAC78604 AF059254 AAC78605 AK310107 BC009344 AAH09344 BC019083 AAH19083 BC030235 BC050618 BC058885 BC071651 DQ893041 ABM83967 DQ896284 ABM87283 XM_006715005 XP_006715068 XM_006715007 XP_006715070 XM_006725474 XP_006725537 XM_006725476 XP_006725539 XM_006725688 XP_006725751 XM_006725690 XP_006725753 XM_006725898 XP_006725961 XM_006725900 XP_006725963 XM_006725985 XP_006726048 XM_006725987 XP_006726050 XM_006726078 XP_006726141 XM_006726080 XP_006726143 XM_011547606 XP_011545908 XR_926081 XR_926082 XR_952207 XR_952208 XR_952941 XR_952942 XR_953003 XR_953004 XR_953077 XR_953078 NM_005510 NP_005501
Function	Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:21750099}.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:9799600}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DOM3Z full length protein - ab158302 from Abcam Category Protein Source Wheat germ Species Human

DXO / DOM3Z Antibody Blocking Peptide - LS-E8346 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DXO / DOM3Z Antibody Blocking Peptide - LS-E18697 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DXO / DOM3Z Antibody Blocking Peptide - LS-E18696 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human DOM3Z Protein - H00001797-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DOM3Z-Antibody-N-term-Y88-Blocking-Peptide - BP6635a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DOM3Z Blocking Peptide - 33R-5573 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DOM3Z - H00001797-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

DOM3Z - H00001797-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

DOM3Z fusion protein - ag1491 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Protein Dom3Z(DOM3Z) - CSB-YP007116HU CSB-EP007116HU CSB-BP007116HU CSB-MP007116HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

DOM3Z - TP305657 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

DXO Recombinant Protein Antigen - NBP2-47478PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DOM3Z Peptide, Human - M34GP04492H from Creative Peptides Category Peptide Source Synthetic. Species Human

Protein Dom3Z (DOM3Z), Recombinant Protein - MBS1010634 from MyBioSource Category Protein Prices $1,170.00, $1,170.00, $1,395.00, $1,395.00, $1,870.00, $1,870.00, $2,335.00, $2,335.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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