| Gene Symbol |
NHEJ1
|
| Entrez Gene |
79840
|
| Alt Symbol |
XLF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nonhomologous end-joining factor 1
|
| Other Description |
XRCC4-like factor|non-homologous end-joining factor 1|protein cernunnos
|
| Swissprots |
Q6IA64 Q96JS9 Q4ZFW7 B8ZZA4 Q9H9Q4
|
| Accessions |
AAX88921 EAW70678 Q9H9Q4 AJ972687 CAI99410 AK022672 BAB14168 BC008210 AAH08210 BC012732 AAH12732 BC030986 AAH30986 CR457291 CAG33572 DB124934 NM_024782 NP_079058
|
| Function |
DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are noncomplementary or partially complementary. {ECO:0000269|PubMed:16439204, ECO:0000269|PubMed:16439205, ECO:0000269|PubMed:17470781}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:16439204, ECO:0000269|PubMed:16439205}.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:16439204}.
|
| Top Pathways |
Non-homologous end-joining
|