| Gene Symbol |
PRDM16
|
| Entrez Gene |
63976
|
| Alt Symbol |
CMD1LL, LVNC8, MEL1, PFM13
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
PR domain containing 16
|
| Other Description |
MDS1/EVI1-like gene 1|PR domain zinc finger protein 16|transcription factor MEL1
|
| Swissprots |
Q9HAZ2 Q8WYJ9 B1AJP9 B1AJP8 B1AJP7 A6NHQ8 B1WB48 Q9C0I8
|
| Accessions |
CCQ43680 EAW71449 EAW71450 EAW71451 Q9HAZ2 AB051462 BAB21766 AB078876 BAB84297 AF294278 AAG33382 AI623202 AK093853 AK094178 AK309078 BC110593 BC161614 AAI61614 BC168363 AAI68363 BQ897896 BX092842 XM_005244772 XP_005244829 XM_005244773 XP_005244830 XM_005244774 XP_005244831 XM_006710814 XP_006710877 XM_011541944 XP_011540246 XM_011541945 XP_011540247 NM_022114 NP_071397 NM_199454 NP_955533
|
| Function |
Binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions also as a repressor of TGF-beta signaling. Isoform 4 may regulate granulocytes differentiation. {ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:14656887, ECO:0000269|PubMed:19049980}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19049980}.
|
| Tissue Specificity |
Expressed in uterus and kidney. Expressed in both cardiomyocytes and interstitial cells. {ECO:0000269|PubMed:11050005, ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:23768516}.
|