SUMO2

Gene Symbol	SUMO2
Entrez Gene	6613
Alt Symbol	HSMT3, SMT3B, SMT3H2, SUMO3, Smt3A
Species	Human
Gene Type	protein-coding
Description	small ubiquitin-like modifier 2
Other Description	SMT3 homolog 2|SMT3 suppressor of mif two 3 homolog 2|sentrin 2|small ubiquitin-related modifier 2|ubiquitin-like protein SMT3A|ubiquitin-like protein SMT3B
Swissprots	Q32Q42 Q6IPZ6 Q96HK1 B2R4I2 P61956
Accessions	EAW89249 EAW89250 P61956 AK024823 AK225090 AK225263 AK311837 BAG34779 BC008450 AAH08450 BC016775 AAH16775 BC022340 AAH22340 BC062713 AAH62713 BC068465 AAH68465 BC070159 AAH70159 BC071645 AAH71645 BC071646 AAH71646 BC107853 AAI07854 BF700114 BG778261 DQ893036 ABM83962 DQ896277 ABM87276 L76416 AAD45399 X99585 CAA67897 NM_001005849 NP_001005849 NM_006937 NP_008868
Function	Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744). {ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:9556629}.
Subcellular Location	Nucleus. Nucleus, PML body.
Tissue Specificity	Broadly expressed. {ECO:0000269|PubMed:9556629}.
Top Pathways	RNA transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SUMO2 overexpression lysate - LY423659 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SUMO-2 (h): 293T Lysate - sc-111926 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

SUMO2 Overexpression Lysate (Native) - NBP2-10389 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SUMO2 Overexpression Lysate (Native) - NBP2-10752 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SUMO2 Overexpression Lysate (Denatured) - H00006613-T02 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human SUMO2 Knockdown Stable Cell Line - CSC-DC015405 from Creative biogene Category Cell Line Species Human

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