| Gene Symbol | SUMO2 |
|---|---|
| Entrez Gene | 6613 |
| Alt Symbol | HSMT3, SMT3B, SMT3H2, SUMO3, Smt3A |
| Species | Human |
| Gene Type | protein-coding |
| Description | small ubiquitin-like modifier 2 |
| Other Description | SMT3 homolog 2|SMT3 suppressor of mif two 3 homolog 2|sentrin 2|small ubiquitin-related modifier 2|ubiquitin-like protein SMT3A|ubiquitin-like protein SMT3B |
| Swissprots | Q32Q42 Q6IPZ6 Q96HK1 B2R4I2 P61956 |
| Accessions | EAW89249 EAW89250 P61956 AK024823 AK225090 AK225263 AK311837 BAG34779 BC008450 AAH08450 BC016775 AAH16775 BC022340 AAH22340 BC062713 AAH62713 BC068465 AAH68465 BC070159 AAH70159 BC071645 AAH71645 BC071646 AAH71646 BC107853 AAI07854 BF700114 BG778261 DQ893036 ABM83962 DQ896277 ABM87276 L76416 AAD45399 X99585 CAA67897 NM_001005849 NP_001005849 NM_006937 NP_008868 |
| Function | Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744). {ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:9556629}. |
| Subcellular Location | Nucleus. Nucleus, PML body. |
| Tissue Specificity | Broadly expressed. {ECO:0000269|PubMed:9556629}. |
| Top Pathways | RNA transport |
SUMO-2 CRISPR/Cas9 KO Plasmid (h) - sc-401111 from Santa Cruz Biotechnology
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SUMO-2 HDR Plasmid (h) - sc-401111-HDR from Santa Cruz Biotechnology
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SUMO-2 Double Nickase Plasmid (h) - sc-401111-NIC from Santa Cruz Biotechnology
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SUMO-2 Double Nickase Plasmid (h2) - sc-401111-NIC-2 from Santa Cruz Biotechnology
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SUMO-2 CRISPR Activation Plasmid (h) - sc-401111-ACT from Santa Cruz Biotechnology
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SUMO-2 CRISPR Activation Plasmid (h2) - sc-401111-ACT-2 from Santa Cruz Biotechnology
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SUMO-2 Lentiviral Activation Particles (h) - sc-401111-LAC from Santa Cruz Biotechnology
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SUMO-2 Lentiviral Activation Particles (h2) - sc-401111-LAC-2 from Santa Cruz Biotechnology
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SUMO-3 siRNA (h) - sc-41083 from Santa Cruz Biotechnology
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SUMO-3 siRNA Plasmid (h) - sc-41083-SH from Santa Cruz Biotechnology
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SUMO-3 shRNA (h) Lentiviral Particles - sc-41083-V from Santa Cruz Biotechnology
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SUMO-2 siRNA (h2) - sc-270536 from Santa Cruz Biotechnology
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SUMO-2 shRNA Plasmid (h2) - sc-270536-SH from Santa Cruz Biotechnology
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SUMO2 RNAi - H00006613-R02 from Novus Biologicals
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SUMO2 RNAi - H00006613-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN20834 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20834 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05936 from Sigma-Aldrich
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SUMO2 siRNA (Human) - CRH4496 from Cohesion Biosciences
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SUMO2 - MBS8231866 from MyBioSource
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shRNA set against Human SUMO2(NM_001005849.1) - SHL020198 from Creative biogene
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shRNA set against Human SUMO2(NM_006937.3) - SHL047798 from Creative biogene
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Human SUMO2 siRNA - orb264998 from Biorbyt
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SUMO2 shRNA Plasmid (Human) - CHH4496 from Cohesion Biosciences
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SUMO2 miRNA 3'UTR clone - MiUTR1H-10064 from Creative biogene
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