| Gene Symbol | ATP2B1 |
|---|---|
| Entrez Gene | 490 |
| Alt Symbol | PMCA1, PMCA1kb |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATPase, Ca++ transporting, plasma membrane 1 |
| Other Description | plasma membrane calcium pump|plasma membrane calcium-transporting ATPase 1 |
| Swissprots | Q16504 Q13819 Q12992 Q93082 Q12993 Q13820 Q13821 P20020 |
| Accessions | AAA58381 AAA58382 AAA58383 AAD09924 AAD09925 EAW97429 EAW97430 EAW97431 EAW97432 EAW97433 EAW97434 P20020 AB208896 BAD92133 AF070606 AK024895 AK027053 AK308723 AY740526 AAV41065 BC015346 AAH15346 BM974301 DQ201776 ABG24240 J04027 AAA74511 M95541 AAA35999 M95542 AAA36000 S49852 AAB24324 U15686 AAA60983 U15687 AAA60984 XM_005268919 XP_005268976 XM_011538407 XP_011536709 XM_011538408 XP_011536710 XM_011538409 XP_011536711 XM_011538410 XP_011536712 XM_011538411 XP_011536713 XM_011538412 XP_011536714 XR_944556 NM_001001323 NP_001001323 NM_001682 NP_001673 |
| Function | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Isoform B is ubiquitously expressed. Isoform C is found in brain cortex, skeletal muscle and heart muscle. Isoform D has only been found in fetal skeletal muscle. Isoform K has been found in small intestine and liver. |
| Top Pathways | Calcium signaling pathway, Salivary secretion, Pancreatic secretion, Mineral absorption, Endocrine and other factor-regulated calcium reabsorption |