| Gene Symbol |
IRAK2
|
| Entrez Gene |
3656
|
| Alt Symbol |
IRAK-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interleukin-1 receptor-associated kinase 2
|
| Other Description |
interleukin-1 receptor associated kinase-2|interleukin-1 receptor-associated kinase-like 2
|
| Swissprots |
Q08AG6 Q5K546 O43187 B4DQZ6
|
| Accessions |
EAW64069 O43187 AF026273 AAB87669 AJ496794 CAD43180 AK299033 BAG61108 AK312841 BAG35695 AL538890 AL556221 BC125184 AAI25185 BG682610 XM_011533680 XP_011531982 XR_245126 NM_001570 NP_001561
|
| Function |
Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. {ECO:0000269|PubMed:10383454, ECO:0000269|PubMed:9374458}.
|
| Tissue Specificity |
Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes. {ECO:0000269|PubMed:9374458}.
|
| Top Pathways |
Apoptosis, Neurotrophin signaling pathway, Tuberculosis
|