| Gene Symbol |
ARHGAP22
|
| Entrez Gene |
58504
|
| Alt Symbol |
RhoGAP2, RhoGap22
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Rho GTPase activating protein 22
|
| Other Description |
rho GTPase-activating protein 22|rho-type GTPase-activating protein 22
|
| Swissprots |
C9JDM2 Q7Z5H3 O00152 B9EGA0 B4DED8 A5YM75 Q6ZSB0 A0AVP7
|
| Accessions |
EAW93125 EAW93126 EAW93127 Q7Z5H3 AK055037 BAG51453 AK055937 AK127586 BAC87044 AK293579 BAG57049 AY324801 AAP85632 BC037890 BC043540 BC047096 BC126444 AAI26445 BC136319 AAI36320 DB338179 DC391765 EF560749 ABQ59059 HG502883 HQ258357 ADR83111 U90908 AAB51057 XM_005270014 XP_005270071 XM_011540002 XP_011538304 XM_011540003 XP_011538305 XM_011540004 XP_011538306 XM_011540005 XP_011538307 XM_011540006 XP_011538308 XM_011540007 XP_011538309 XM_011540008 XP_011538310 XM_011540009 XP_011538311 XM_011540010 XP_011538312 XM_011540011 XP_011538313 XM_011540012 XP_011538314 XM_011540013 XP_011538315 XM_011540014 XP_011538316 XM_011540015 XP_011538317 NM_001256027 NM_001256024 NP_001242953 NM_001256025 NP_001242954 NM_001256026 NP_001242955 NM_021226 NP_067049 NR_045675
|
| Function |
Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mainly cytoplasmic. Some fraction is nuclear (By similarity). {ECO:0000250}.
|