Gene Symbol | ARHGAP22 |
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Entrez Gene | 58504 |
Alt Symbol | RhoGAP2, RhoGap22 |
Species | Human |
Gene Type | protein-coding |
Description | Rho GTPase activating protein 22 |
Other Description | rho GTPase-activating protein 22|rho-type GTPase-activating protein 22 |
Swissprots | C9JDM2 Q7Z5H3 O00152 B9EGA0 B4DED8 A5YM75 Q6ZSB0 A0AVP7 |
Accessions | EAW93125 EAW93126 EAW93127 Q7Z5H3 AK055037 BAG51453 AK055937 AK127586 BAC87044 AK293579 BAG57049 AY324801 AAP85632 BC037890 BC043540 BC047096 BC126444 AAI26445 BC136319 AAI36320 DB338179 DC391765 EF560749 ABQ59059 HG502883 HQ258357 ADR83111 U90908 AAB51057 XM_005270014 XP_005270071 XM_011540002 XP_011538304 XM_011540003 XP_011538305 XM_011540004 XP_011538306 XM_011540005 XP_011538307 XM_011540006 XP_011538308 XM_011540007 XP_011538309 XM_011540008 XP_011538310 XM_011540009 XP_011538311 XM_011540010 XP_011538312 XM_011540011 XP_011538313 XM_011540012 XP_011538314 XM_011540013 XP_011538315 XM_011540014 XP_011538316 XM_011540015 XP_011538317 NM_001256027 NM_001256024 NP_001242953 NM_001256025 NP_001242954 NM_001256026 NP_001242955 NM_021226 NP_067049 NR_045675 |
Function | Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mainly cytoplasmic. Some fraction is nuclear (By similarity). {ECO:0000250}. |
ARHGAP22 CRISPR/Cas9 KO Plasmid (h) - sc-407467 from Santa Cruz Biotechnology
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ARHGAP22 HDR Plasmid (h) - sc-407467-HDR from Santa Cruz Biotechnology
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ARHGAP22 Double Nickase Plasmid (h) - sc-407467-NIC from Santa Cruz Biotechnology
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ARHGAP22 Double Nickase Plasmid (h2) - sc-407467-NIC-2 from Santa Cruz Biotechnology
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ARHGAP22 CRISPR Activation Plasmid (h) - sc-407467-ACT from Santa Cruz Biotechnology
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ARHGAP22 CRISPR Activation Plasmid (h2) - sc-407467-ACT-2 from Santa Cruz Biotechnology
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ARHGAP22 Lentiviral Activation Particles (h) - sc-407467-LAC from Santa Cruz Biotechnology
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ARHGAP22 Lentiviral Activation Particles (h2) - sc-407467-LAC-2 from Santa Cruz Biotechnology
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ARHGAP22 siRNA (h) - sc-90662 from Santa Cruz Biotechnology
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ARHGAP22 shRNA Plasmid (h) - sc-90662-SH from Santa Cruz Biotechnology
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ARHGAP22 shRNA (h) Lentiviral Particles - sc-90662-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU034731 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3416 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3416 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03028 from Sigma-Aldrich
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ARHGAP22 siRNA (Human) - CRJ1732 from Cohesion Biosciences
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ARHGAP22 - MBS8236189 from MyBioSource
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shRNA set against Human ARHGAP22 (NM_021226.3) - SHH239398 from Creative biogene
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Human ARHGAP22 siRNA - orb272233 from Biorbyt
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ARHGAP22 shRNA Plasmid (Human) - CHJ1732 from Cohesion Biosciences
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ARHGAP22 miRNA 3'UTR clone - MiUTR3H-11327 from Creative biogene
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